A potential molecular mechanism for hypersensitivity caused by formalin-inactivated vaccines

被引：0
作者：
Amin Moghaddam
Wieslawa Olszewska
Belinda Wang
John S Tregoning
Rebecca Helson
Quentin J Sattentau
Peter J M Openshaw
机构：
[1] The Sir William Dunn School of Pathology,Department of Respiratory Medicine
[2] The University of Oxford,undefined
[3] Wright Fleming Institute,undefined
[4] Imperial College London,undefined
来源：
Nature Medicine | 2006年 / 12卷
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摘要：
Heat, oxidation and exposure to aldehydes create reactive carbonyl groups on proteins, targeting antigens to scavenger receptors. Formaldehyde is widely used in making vaccines, but has been associated with atypical enhanced disease during subsequent infection with paramyxoviruses. We show that carbonyl groups on formaldehyde-treated vaccine antigens boost T helper type 2 (TH2) responses and enhance respiratory syncytial virus (RSV) disease in mice, an effect partially reversible by chemical reduction of carbonyl groups.
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页码：905 / 907
页数：2
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