Synthesis and anti-inflammatory activity of 1,2-3-substituted 2a1,4,5-triazacyclopenta[cd]indene derivatives

被引：0
作者：
Sumalatha Sanivarapu
Namratha Vaddiraju
Lakshmi Velide
机构：
[1] Jawaharlal Nehru Technological University,Department of Chemistry
[2] Green Evolution Laboratories,Department of Chemistry
[3] Wangapally Village,Department of Life Sciences
[4] Satavahana University,undefined
[5] Kakatiya University,undefined
来源：
Medicinal Chemistry Research | 2019年 / 28卷
关键词：
Acyl bromides; 2-Aminopyrimidine; Anti-inflammatory; Synthesis; Imidazo[1; 2-a] pyrimidines;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The present study reports the synthesis of 1,2-3-substituted-2a1,4,5-triazacyclopenta[cd]indene derivatives. The synthetic methodology includes some of the prominent reaction steps as specified in sequence (i) Bromination of acetophenones (ii) Condensation of 2-bromo-1-(substituted phenyl) ethanone derivatives with 2-aminopyrimidine, and (iii) Coupling of imidazo[1,2-a]pyrimidine derivatives with 1,2-diaryl/diaklylethynes. The structures of the newly synthesized derivatives have been determined by 1H NMR, 13C NMR, LC-MS, and IR spectral analysis. Furthermore, these derivatives were screened for their preliminary anti-inflammatory activities using Carrageenan induced paw edema test method. These promising screening results suggested a huge potential for the molecular diversity from present compounds that can be inflated to better lead candidates.
引用
收藏
页码：1461 / 1470
页数：9
相关论文
共 118 条
[1]  
Avik KB(2015)Synthesis of imidazo[1,2-a]pyridines: a decade update Chem Commun 51 1555-1575
[2]  
Sougata S(1999)Ribosomal protein S14 of Saccharomyces cerevisiae regulates its expression by binding to RPS14B pre-mRNA and to 18S rRNA Mol Cell Biol 19 826-834
[3]  
Kamarul M(2013)Synthesis and anti-inflammatory evaluation of novel benzimidazole and imidazopyridine derivatives ACS Med Chem Lett 4 69-74
[4]  
Alakananda H(2011)Design and synthesis of imidazopyridine analogues as inhibitors of phosphoinositide 3-kinase signaling and angiogenesis J Med Chem 54 2455-2466
[5]  
Fewell SW(2016)Synthesis and antibacterial activity of some novel hydrazone derivatives of anacardic acid linked with 1, 4-disubstituted 1,2,3-triazole ring J Applicable Chem 5 783-791
[6]  
Woolford JL(2017)Synthesis and anti-inflammatory activity of hydrazide-hydrazones bearing anacardic acid and 1,2,3-triazole ring based hybrids Orient J Chem 33 2930-2936
[7]  
Gaozhi C(2015)Imidazopyridines as a source of biological activity and their pharmacological potentials-Infrared and Raman spectroscopic evidence of their content in pharmaceuticals and plant materials Bioorg Med Chem 23 6087-6099
[8]  
Zhiguo L(2016)Urea as mild and efficient additive for palladium catalyzed Sonogashira cross coupling reaction Tetrahedron Lett 57 914-916
[9]  
Yali Z(1972)Imidazo[1,2-a]pyridine anthelmintic and antifungal agents J Med Chem 15 982-985
[10]  
Xiaoou S(2010)A single-step synthesis of enynes: Pd-catalyzed arylalkynylation of aryl iodides, internal alkynes, and alkynylsilanes Org Letts 12 1300-1303
12345678910