Vascular Endothelial Growth Factor and Its Receptors in the Placental Villi of Pregnant Patients with Pre-Eclampsia

被引：0
作者：
E. A. Dubova
K. A. Pavlov
V. M. Lyapin
A. I. Shchyogolev
G. T. Sukhikh
机构：
[1] Ministry of Health and Social Development of the Russian Federation,V. I. Kulakov Center of Obstetrics, Gynecology, and Perinatology
来源：
Bulletin of Experimental Biology and Medicine | 2013年 / 154卷
关键词：
pre-eclampsia; placenta; vascular endothelial growth factor (VEGF); VEGFR;
D O I：
暂无
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学科分类号：
摘要：
Comparative morphological study of the placentas from women with pre-eclampsia of different severity was carried out. The expression of vascular endothelial growth factor and its receptors (VEGFR-1, VEGFR-2, VEGFR-3) was studied by immunohistochemical methods. Branched angiogenesis processes predominated in the placentas of patients with pre-eclampsia. The syncytiocapillary membranes were thickened, the number of syncytial buds was greater than normally. Immunohistochemical studies showed high expression of VEGF and VEGFR-1 and low expression of VEGFR-2 in the placental villous structures.
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页码：792 / 795
页数：3
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