HIV and Stem Cell Transplantation

被引：0
作者：
Ignacio A. Echenique
George E. Nelson
Valentina Stosor
Christine M. Durand
机构：
[1] Northwestern University Feinberg School of Medicine,Division of Infectious Diseases, Department of Medicine
[2] Northwestern University Feinberg School of Medicine,Division of Organ Transplantation, Department of Surgery
[3] Johns Hopkins School of Medicine,Division of Infectious Diseases, Department of Medicine
[4] Johns Hopkins School of Medicine,Division of Infectious Diseases
来源：
Current Infectious Disease Reports | 2014年 / 16卷
关键词：
AIDS; Allogeneic stem cell transplantation; Antiretroviral therapy; Autologous stem cell transplantation; Bone marrow transplantation; GVHD; HIV; HIV cure; HIV eradication; HIV reservoir; Hodgkin lymphoma; Non-Hodgkin lymphoma; Stem cell transplantation;
D O I：
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摘要：
In human immunodeficiency virus (HIV)-infected persons, the incidence of hematologic malignancies, including leukemia and lymphoma, is increased despite the use of successful antiretroviral therapy. Hematopoietic stem cell transplantation (SCT) is emerging as a safe and effective therapy for HIV-infected persons with hematologic malignancies. Management of these patients is complicated by drug–drug interactions involving antiretroviral therapy (ART) that may impact conditioning agent efficacy and metabolism of immunosuppressive medications and potentiate drug toxicities. As such, optimal strategies for ART remain controversial. We discuss recent advances, controversies, and future directions related to SCT in HIV-infected persons, including the investigation of allogeneic SCT as a strategy for HIV cure.
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