Transient Transmission of Hepatitis C Virus from Mothers to Newborns

被引：0

作者：

M. Ketzinel-Gilad

S. L. Colodner

R. Hadary

E. Granot

D. Shouval

E. Galun

机构：

[1] Liver Unit,

[2] Hadassah University Hospital,undefined

[3] Ein Kerem,undefined

[4] Jerusalem,undefined

[5] Israel,undefined

[6] Department of Pediatrics,undefined

[7] Hadassah University Hospital,undefined

[8] Ein Kerem,undefined

[9] Jerusalem,undefined

[10] Israel,undefined

[11] Goldyne Savad Gene Therapy Institute,undefined

[12] Hadassah University Hospital,undefined

[13] PO Box 12000,undefined

[14] Ein Kerem,undefined

[15] 91120 Jerusalem,undefined

[16] Israel e-mail: galun@md2.huji.ac.il,undefined

来源：

European Journal of Clinical Microbiology and Infectious Diseases | 2000年 / 19卷

关键词：

Nucleotide; Hepatitis; Sequence Analysis; Newborn Infant; Replication Rate;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A study was performed in Israel to determine the rate of mother-to-infant HCV transmission in newborns at risk. A group of 22 HCV-infected mothers and their 23 newborns were followed up from early after birth by testing their serum for the presence of HCV antibodies and HCV-RNA. Antibody against HCV was detected in the blood of all newborns immediately after birth, but dropped to low or undetectable levels by 7 months of age. HCV-RNA was detected 2 days after birth in the blood of five infants (22%) but fell to undetectable levels by 6 months. HCV-HVR1 sequence analysis performed in one mother-infant pair on the second day after birth revealed two nucleotide changes. Two months later the same sequence was detected again in the HVR1, suggesting a very low replication rate. Thus, the study showed that vertically transmitted HCV was eliminated in all newborn infants by 6 months after delivery, with concomitant disappearance of HCV antibodies. The mechanism of HCV elimination in newborns at risk remains to be elucidated.

引用

页码：267 / 274

页数：7