Methodological Lessons from Clinical Trials and the Future of Microbicide Research

被引：0
作者：
Ariane van der Straten
Elizabeth T. Montgomery
Miriam Hartmann
Alexandra Minnis
机构：
[1] RTI International,Women’s Global Health Imperative
[2] University of California San Francisco,Center for AIDS Prevention Studies, Department of Medicine
[3] University of California Berkeley,School of Public Health
来源：
Current HIV/AIDS Reports | 2013年 / 10卷
关键词：
Topical vaginal microbicides; Rectal microbicides; Microbicide trial; Sexual risk behavior; Gel; Vaginal ring; Clinical trials; Adherence measurement; Biomarkers; Pre-exposure Prophylaxis (PrEP); HIV prevention;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Interpretation of microbicide trial results has been compromised by challenges to accurate measurement of product adherence and sexual risk behaviors. This article provides an evaluation of the methods used to measure adherence and other sensitive behaviors relevant to assessment of product safety and effectiveness in recently completed trials of vaginal and rectal microbicides. We review the strengths and limitations of existing and novel behavioral measurement strategies and provide recommendations for future trial design with the goal of facilitating the development and identification of safe and effective microbicides for HIV prevention.
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页码：89 / 102
页数：13
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