Prognostic value of automated KI67 scoring in breast cancer: a centralised evaluation of 8088 patients from 10 study groups

被引：0

作者：

Mustapha Abubakar

Nick Orr

Frances Daley

Penny Coulson

H. Raza Ali

Fiona Blows

Javier Benitez

Roger Milne

Herman Brenner

Christa Stegmaier

Arto Mannermaa

Jenny Chang-Claude

Anja Rudolph

Peter Sinn

Fergus J. Couch

Peter Devilee

Rob A. E. M. Tollenaar

Caroline Seynaeve

Jonine Figueroa

Mark E. Sherman

Jolanta Lissowska

Stephen Hewitt

Diana Eccles

Maartje J. Hooning

Antoinette Hollestelle

John W. M. Martens

Carolien H. M. van Deurzen

kConFab Investigators

Manjeet K. Bolla

Qin Wang

Michael Jones

Minouk Schoemaker

Jelle Wesseling

Flora E. van Leeuwen

Laura Van ‘t Veer

Douglas Easton

Anthony J. Swerdlow

Mitch Dowsett

Paul D. Pharoah

Marjanka K. Schmidt

Montserrat Garcia-Closas

机构：

[1] The Institute of Cancer Research,Division of Genetics and Epidemiology

[2] The Institute of Cancer Research,Breast Cancer Now Toby Robins Research Centre, Division of Breast Cancer Research

[3] Cancer Research UK Cambridge Institute,Centre for Cancer Genetic Epidemiology, Department of Oncology

[4] University of Cambridge,Human Genetics Group, Human Cancer Genetics Program

[5] University of Cambridge,Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health

[6] Spanish National Cancer Research Centre (CNIO),Division of Clinical Epidemiology and Aging Research

[7] Centro de Investigacion en Red de Enfermedades Raras (CIBERER),Division of Preventive Oncology

[8] Cancer Epidemiology Centre,School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, Cancer Center of Eastern Finland

[9] Cancer Council Victoria,Imaging Center, Department of Clinical Pathology

[10] The University of Melbourne,Division of Cancer Epidemiology

[11] German Cancer Research Center (DKFZ),Department of Pathology, Institute of Pathology

[12] German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT),Department of Laboratory Medicine and Pathology

[13] German Cancer Consortium (DKTK),Department of Human Genetics and Department of Pathology

[14] German Cancer Research Center (DKFZ),Department of Surgery

[15] Saarland Cancer Registry,Department of Medical Oncology, Family Cancer Clinic

[16] University of Eastern Finland,Usher Institute of Population Health Sciences and Informatics

[17] Kuopio University Hospital,Divisions of Cancer Epidemiology and Genetics

[18] German Cancer Research Center (DKFZ),Department of Cancer Epidemiology and Prevention

[19] University Cancer Center Hamburg,Faculty of Medicine Academic Unit of Cancer Sciences

[20] University Medical Center Hamburg-Eppendorf,Family Cancer Clinic, Department of Medical Oncology

[21] Heidelberg University Hospital,Department of Pathology

[22] Mayo Clinic,Department of Genetics

[23] Leiden University Medical Center,Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care

[24] Leiden University Medical Center,Division of Molecular Pathology

[25] Erasmus MC Cancer Institute,Division of Psychosocial Research and Epidemiology

[26] The University of Edinburgh,Division of Breast Cancer Research

[27] National Cancer Institute,Academic Department of Biochemistry

[28] M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology,undefined

[29] Laboratory of Pathology,undefined

[30] National Cancer Institute,undefined

[31] National Institutes of Health,undefined

[32] Southampton General Hospital,undefined

[33] Erasmus MC Cancer Institute,undefined

[34] Erasmus MC Cancer Institute,undefined

[35] QIMR Berghofer Medical Research Institute,undefined

[36] University of Cambridge,undefined

[37] Netherlands Cancer Institute,undefined

[38] Antoni van Leeuwenhoek Hospital,undefined

[39] Netherlands Cancer Institute,undefined

[40] Antoni van Leeuwenhoek Hospital,undefined

[41] The Institute of Cancer Research,undefined

[42] Royal Marsden Hospital,undefined

来源：

Breast Cancer Research | / 18卷

关键词：

Breast cancer; Automated KI67; Visual KI67; Prognostication;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

共 182 条

[1]

Goldhirsch A(2015)Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013 Ann Oncol. 12 296-301

[2]

Winer EP(2013)Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up Ann Oncol. 22 2013-301

[3]

Coates AS(2015)Ki67—no evidence for its use in node-positive breast cancer Nat Rev Clin Oncol. 12 296-20

[4]

Gelber RD(2005)Proliferation marker Ki-67 in early breast cancer J Clin Oncol 23 7212-83

[5]

Piccart-Gebhart M(2010)Ki67 in breast cancer: prognostic and predictive potential Lancet Oncol 11 174-13

[6]

Thürlimann B(2007)Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12 155 patients Br J Cancer 96 1504-34

[7]

Senkus E(2008)Proliferation markers and survival in early breast cancer: a systematic review and meta-analysis of 85 studies in 32,825 patients Breast 17 323-64

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Kyriakides S(2011)Assessment of Ki67 in breast cancer: recommendations from the International Ki67 in Breast Cancer Working Group J Natl Cancer Inst 103 1656-906

[9]

Penault-Llorca F(2013)An International Ki67 Reproducibility Study J Natl Cancer Inst 105 1897-43

[10]

Poortmans P(2013)Interobserver concordance of Ki67 labeling index in breast cancer: Japan Breast Cancer Research Group Ki67 Ring Study Cancer Sci 104 1539-44

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