Relationship between insulin resistance and subclinical atherosclerosis in individuals with and without type 2 diabetes mellitus

被引：30

作者：

Fakhrzadeh H. ^{[1
]}

Sharifi F. ^{[1
]}

Alizadeh M. ^{[1
]}

Arzaghi S.M. ^{[1
]}

Tajallizade-Khoob Y. ^{[1
]}

Tootee A. ^{[2
]}

Alatab S. ^{[2
]}

Mirarefin M. ^{[1
]}

Badamchizade Z. ^{[2
]}

Kazemi H. ^{[3
]}

机构：

[1] Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Elderly Health Research Center, No 4th, Ostad Nejatollahi Street, Enghelab Avenue, Tehran

[2] Tehran University of Medical Sciences, Endocrinology and Metabolism Research Center, Tehran

[3] Pediatrics, Shahed University, Faculty of Medicine, Tehran

来源：

Journal of Diabetes & Metabolic Disorders | / 15卷 / 1期

关键词：

Atherosclerosis; Cardiovascular diseases; Coronary artery calcium score (CACS); Diabetes mellitus; Flow mediated dilation (FMD); HOMA-IR; Insulin resistance;

D O I：

10.1186/s40200-016-0263-5

中图分类号：

学科分类号：

摘要：

Background: Insulin resistance is of utmost importance as an underlying mechanism for increased risk of cardiovascular disease (CVD). We assessed the association between Homeostatic Model Assessment (HOMA-IR) and two surrogate subclinical atherosclerosis markers (SCA) among individuals with and without type 2 diabetes (DM), those who did not have any clinical presentation of the CVD. Methods: In a cross-sectional study, 208 participants (105 diabetics and 103 non-diabetics) were enrolled from referred patients with diabetes to an academic outpatient clinic and their non-diabetic relatives in-law. Fasting serum levels of insulin, blood glucose and lipid profile, were measured. Anthropometric and blood pressure were measuremented standardly. Body Mass Index (BMI) and Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) index were calculated. Coronary Artery Calcium Score(CACS) was measured using a Multi-Detctor CT scanner. Flow mediated dilation (FMD) was measured using bimode ultrasonography (with linear transducer 13,000 MHZ). Univariate and multivariate logistic regression models were used to evaluate the association between these SCA markers and HOMA index in adjusting models. Results: CACS and HOMA-IR were higher and FMD was lower in diabetic participants than non-diabetic ones (P < 0.01) In a stepwise logistic regression model, CACS and FMD were associated with HOMA-IR (odds ratio = 1.778; 95 % confidence interval (CI): 1.211-2.726 and odds ratio = 1.557; 95 % CI: 1.601-2.275, respectively) in non-diabetics but not among diabetic participants. Conclusions: CACS and FMD are related to insulin resistance among non-diabetic individuals, but we could not find this relationship among diabetic patients. © 2016 The Author(s).

引用

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