Multicentric Castleman's disease combined with polyserositis and POEMS syndrome: case report and review article

被引：1
作者：
Ulas, Sevtap Tugce [1 ]
Dasdelen, Suha [2 ,3 ]
机构：
[1] Charite Univ Med Berlin, Klin Radiol, Campus Mitte, Berlin, Germany
[2] Vivantes Humboldt Klinikum, Klin Nephrol, Nordgraben 2, D-13509 Berlin, Germany
[3] Private Univ Klin Witten Herdecke, Witten, Germany
来源：
INTERNIST | 2021年 / 62卷 / 07期
关键词：
Multicentric Castleman's disease; Monoclonal gammopathy of undetermined significance; Vascular endothelial growth factor (VEGF); Interleukin-6; Antibodies; monoclonal; HYALINE VASCULAR-TYPE; GROWTH-FACTOR LEVELS; MONOCLONAL-ANTIBODY; MANIFESTATIONS; PATHOGENESIS; SILTUXIMAB; SPECTRUM; THERAPY; BIOLOGY;
D O I：
10.1007/s00108-021-01063-4
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Castleman disease (CD) is a very rare disorder characterised by hyperplasia of the lymphoid tissue. The aetiology varies considerably and includes autoimmunological, infectious, autoinflammatory and paraneoplastic diseases (e.g. MGUS with POEMS syndrome). What they all have in common is usually a dysregulation/overproduction of certain cytokines and growth factors (including interleukin 6 and VEGF). The sum of these changes sometimes causes very heterogeneous symptoms and thus often makes early diagnosis difficult. The prognosis of unrecognised and untreated disease is very serious and has an average 5-year survival rate of 55-77%. The present paper describes the case of a 79-year-old patient with refractory polyserositis who was correctly diagnosed after > 8 years.
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收藏
页码：777 / 785
页数：9
相关论文
共 43 条
  • [1] Idiopathic multicentric Castleman disease preceded by cutaneous plasmacytosis successfully treated by tocilizumab
    Aita, Tetsuro
    Hamaguchi, Sugihiro
    Shimotani, Yoko
    Nakamoto, Yohei
    [J]. BMJ CASE REPORTS, 2020, 13 (11)
  • [2] Increased mTOR activation in idiopathic multicentric Castleman disease
    Arenas, Daniel J.
    Floess, Katherine
    Kobrin, Dale
    Pai, Ruth-Anne Langan
    Srkalovic, Maya B.
    Tamakloe, Mark-Avery
    Rasheed, Rozena
    Ziglar, Jasira
    Khor, Johnson
    Parente, Sophia A. T.
    Pierson, Sheila K.
    Martinez, Daniel
    Wertheim, Gerald B.
    Kambayashi, Taku
    Baur, Joseph
    Teachey, David T.
    Fajgenbaum, David C.
    [J]. BLOOD, 2020, 135 (19) : 1673 - 1684
  • [3] Barete S, 2010, ARCH DERMATOL, V146, P615, DOI 10.1001/archdermatol.2010.100
  • [4] The Great Mimickers: Castleman Disease
    Bonekamp, David
    Hruban, Ralph H.
    Fishman, Elliot K.
    [J]. SEMINARS IN ULTRASOUND CT AND MRI, 2014, 35 (03) : 263 - 271
  • [5] Pro-inflammatory State in Monoclonal Gammopathy of Undetermined Significance and in Multiple Myeloma is Characterized by Low Sialylation of Pathogen-Specific and Other Monoclonal Immunoglobulins
    Bosseboeuf, Adrien
    Allain-Maillet, Sophie
    Mennesson, Nicolas
    Tallet, Anne
    Rossi, Cedric
    Garderet, Laurent
    Caillot, Denis
    Moreau, Philippe
    Piver, Eric
    Girodon, Francois
    Perreault, Helene
    Brouard, Sophie
    Nicot, Arnaud
    Bigot-Corbel, Edith
    Hermouet, Sylvie
    Harb, Jean
    [J]. FRONTIERS IN IMMUNOLOGY, 2017, 8
  • [6] DYSREGULATED INTERLEUKIN-6 EXPRESSION PRODUCES A SYNDROME RESEMBLING CASTLEMANS DISEASE IN MICE
    BRANDT, SJ
    BODINE, DM
    DUNBAR, CE
    NIENHUIS, AW
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1990, 86 (02) : 592 - 599
  • [7] Analysis of Inflammatory and Anemia-Related Biomarkers in a Randomized, Double-Blind, Placebo-Controlled Study of Siltuximab (Anti-IL6 Monoclonal Antibody) in Patients With Multicentric Castleman Disease
    Casper, Corey
    Chaturvedi, Shalini
    Munshi, Nikhil
    Wong, Raymond
    Qi, Ming
    Schaffer, Michael
    Bandekar, Rajesh
    Hall, Brett
    van de Velde, Helgi
    Vermeulen, Jessica
    Reddy, Manjula
    van Rhee, Frits
    [J]. CLINICAL CANCER RESEARCH, 2015, 21 (19) : 4294 - 4304
  • [8] Castleman B, 1954, N Engl J Med, V251, P396
  • [9] Cousins E, 2014, RECENT RESULTS CANC, V193, P227, DOI 10.1007/978-3-642-38965-8_13
  • [10] The utility of plasma vascular endothelial growth factor levels in the diagnosis and follow-up of patients with POEMS syndrome
    D'Souza, Anita
    Hayman, Suzanne R.
    Buadi, Francis
    Mauermann, Michelle
    Lacy, Martha Q.
    Gertz, Morie A.
    Kyle, Robert A.
    Kumar, Shaji
    Greipp, Philip R.
    Lust, John A.
    Russell, Stephen J.
    Zeldenrust, Steven
    Dingli, David
    Witzig, Thomas E.
    Rajkumar, S. Vincent
    Dispenzieri, Angela
    [J]. BLOOD, 2011, 118 (17) : 4663 - 4665
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