Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy

被引：0
作者：
Zane Jaunmuktane
Simon Mead
Matthew Ellis
Jonathan D. F. Wadsworth
Andrew J. Nicoll
Joanna Kenny
Francesca Launchbury
Jacqueline Linehan
Angela Richard-Loendt
A. Sarah Walker
Peter Rudge
John Collinge
Sebastian Brandner
机构：
[1] The National Hospital for Neurology and Neurosurgery,Division of Neuropathology
[2] Medical Research Council Prion Unit,Department of Neurodegenerative Disease
[3] UCL Institute of Neurology,undefined
[4] National Prion Clinic,undefined
[5] The National Hospital for Neurology and Neurosurgery,undefined
[6] MRC Clinical Trials Unit at University College London,undefined
来源：
Nature | 2015年 / 525卷
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摘要：
Treatment of children with human cadaver-derived growth hormone (c-hGH) contaminated with prions resulted in transmission of Creutzfeldt–Jakob disease (CJD); unexpectedly, in an autopsy study of eight such iCJD patients, the authors found amyloid-β deposition in the grey matter typical of that seen in Alzheimer's disease and amyloid-β in the blood vessel walls characteristic of cerebral amyloid angiopathy, consistent with iatrogenic transmission of amyloid-β pathology in addition to CJD and suggests that healthy c-hGH-exposed individuals may also be at risk of Alzheimer's disease and cerebral amyloid angiopathy.
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页码：247 / 250
页数：3
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