The hypoxia–lactate axis tempers inflammation

被引：0
作者：
Lionel B. Ivashkiv
机构：
[1] Research Institute and David Z. Rosensweig Genomics Research Center,
[2] Hospital for Special Surgery,undefined
[3] Department of Medicine and Program in Immunology and Microbial Pathogenesis,undefined
[4] Weill Cornell Medicine,undefined
来源：
Nature Reviews Immunology | 2020年 / 20卷
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摘要：
Hypoxia and glycolysis have long been appreciated to promote immune cell activation. In 2019, several studies highlighted a counterbalancing homeostatic function for the glycolytic metabolite lactate. Lactate directly suppresses signalling pathways and modifies histones to play an important role in regulating macrophage polarization, tumour immunity and antiviral responses.
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页码：85 / 86
页数：1
相关论文
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