Variations in the human CC chemokine eotaxin gene

被引：0
作者：
M Miyamasu
T Sekiya
K Ohta
C Ra
O Yoshie
K Yamamoto
N Tsuchiya
K Tokunaga
K Hirai
机构：
[1] University of Tokyo Graduate School of Medicine,Department of Allergy and Rheumatology
[2] University of Tokyo Graduate School of Medicine,Department of Human Genetics
[3] University of Tokyo Graduate School of Medicine,Department of Bioregulatory Function
[4] Teikyo University,Department of Internal Medicine
[5] Advanced Medical Research Center,Department of Molecular Cell Immunology and Allergology
[6] Nihon University School of Medicine,Department of Microbiology
[7] Kinki University School of Medicine,undefined
[8] Laboratory of Host Defenses,undefined
[9] NIAID,undefined
[10] NIH,undefined
来源：
Genes & Immunity | 2001年 / 2卷
关键词：
eotaxin; SNP; bronchial asthma; promoter;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The CC chemokine eotaxin (CCL11) plays a major role in the recruitment and activation of eosinophils in allergic disorders. In the present study, we performed polymorphism screening of the coding and promoter regions of the eotaxin gene (SCYA11). A G to A single nucleotide substitution was detected at position 67, which resulted in a non-conservative amino acid change of Ala at position 23 to Thr (A23T) within the signal peptide. Two single nucleotide substitutions, ie, C to T at position −426 (−426C>T), and A to G at position −384 (−384A>G), were detected in the 5′-flanking regions. Significant linkage disequilibrium was observed between positions −426 and −384, and also between −384 and +67. No significant association was observed between these variations and susceptibility to asthma.
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页码：461 / 463
页数：2
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