Reversibility of Heat-Induced Denaturation of the Recombinant Human Megakaryocyte Growth and Development Factor

[1] Bartley T. D.(1994)Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MPL Cell 77 1117-1124

[2] Boberger J.(1994)Stimulation of megakaryocytopoiesis and thromboiesis by the c-mpl ligand Nature 369 533-538

[3] Hunt P.(1994)Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production Nature 369 565-568

[4] Li Y.-S.(1995)Physiology and preclinical studies of thrombopoietin Curr. Opinion Hematol. 2 172-176

[5] Lu H. S.(1997)Randomized, blinded, placebo-controlled phase 1 trial of pegylated recombinant human megakaryocyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer Blood 89 3118-3128

[6] Martin F.(1997)Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer New Engl. J. Med. 336 404-409

[7] Chang M.-S.(1992)Formulation concerns of protein drugs Drug Dev. Ind. Pharm. 18 1311-1354

[8] Samal B.(1994)Strategies to suppress aggregation of recombinant keratinocyte growth factor during liquid formulation development J. Pharm. Sci. 83 1657-1661

[9] Nichol J. L.(1996)Stabilization of recombinant human keratinocyte growth factor by osmolytes and salts J. Pharm. Sci. 85 419-426

[10] Swift S.(1997)An improved function for fitting sedimentation velocity data for low-molecular-weight solutes Biophys. J. 72 435-444

[1] Bartley T. D.(1994)Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MPL Cell 77 1117-1124

[2] Boberger J.(1994)Stimulation of megakaryocytopoiesis and thromboiesis by the c-mpl ligand Nature 369 533-538

[3] Hunt P.(1994)Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production Nature 369 565-568

[4] Li Y.-S.(1995)Physiology and preclinical studies of thrombopoietin Curr. Opinion Hematol. 2 172-176

[5] Lu H. S.(1997)Randomized, blinded, placebo-controlled phase 1 trial of pegylated recombinant human megakaryocyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer Blood 89 3118-3128

[6] Martin F.(1997)Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer New Engl. J. Med. 336 404-409

[7] Chang M.-S.(1992)Formulation concerns of protein drugs Drug Dev. Ind. Pharm. 18 1311-1354

[8] Samal B.(1994)Strategies to suppress aggregation of recombinant keratinocyte growth factor during liquid formulation development J. Pharm. Sci. 83 1657-1661

[9] Nichol J. L.(1996)Stabilization of recombinant human keratinocyte growth factor by osmolytes and salts J. Pharm. Sci. 85 419-426

[10] Swift S.(1997)An improved function for fitting sedimentation velocity data for low-molecular-weight solutes Biophys. J. 72 435-444