A Group of miRNA as Candidates for Prognostic Biomarkers of Gastric Cancer Metastasis

被引：0
作者：
F. M. Kipkeeva
Т. А. Muzaffarova
M. P. Nikulin
P. V. Apanovich
M. N. Narimanov
O. A. Malikhova
N. E. Kushlinskii
I. S. Stilidi
A. V. Karpukhin
机构：
[1] N. P. Bochkov Research Centre for Medical Genetics,N. N. Blokhin National Medical Research Center of Oncology
[2] Ministry of Health of the Russian Federation,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2020年 / 169卷
关键词：
gastric cancer; metastasis; miR-34a; miR-146a; miR-335;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
An association was found between reduced expression of miR-34a, miR-146a with both metastasis to regional lymph nodes (relative risk RR=10.50 and RR=5.25, respectively) and the development of distant metastases (RR=9.50 and RR=4, 40, respectively) in gastric cancer. They are excellent classifiers: AUC>0.9 for both miRNAs. The association of miR-335 expression with metastasis to the lymph nodes is much weaker, but it is also a good classifier for identifying a group with distant metastasis (RR=5.90). A correlation was found between the expression of miR-34a and miR-146a during metastasis, which is absent in non-metastatic tumors. Thus, miR-34a, miR-146a, and miR-335 miRNAs can be proposed as candidates for biomarkers of the risk of gastric cancer metastasis.
引用
收藏
页码：77 / 80
页数：3
相关论文
共 82 条
[1]  
Dohi O(2013)Epigenetic silencing of miR-335 and its host gene MEST in hepatocellular carcinoma Int. J. Oncol. 42 411-418
[2]  
Yasui K(2014)Circulating miR-222 in plasma and its potential diagnostic and prognostic value in gastric cancer Med. Oncol. 31 164-224
[3]  
Gen Y(2018)MiR-NA-34a reversed TGF-beta-induced epithelial-mesenchymal transition via suppression of SMAD4 in NPC cells Biomed. Pharmacother. 106 217-4284
[4]  
Takada H(2011)Clinical significance of miR-146a in gastric cancer cases Clin. Cancer Res. 17 4277-197
[5]  
Endo M(2010)Elevated expression of mature miR-21 and miR-155 in cancerous gastric tissues from Chinese patients with gastric cancer J. Biomed. Res. 24 187-152
[6]  
Tsuji K(2008)Endogenous human microRNAs that suppress breast cancer metastasis Nature. 451 147-890
[7]  
Konishi C(2009)Epithelialmesenchymal transitions in development and disease Cell. 139 871-1407
[8]  
Yamada N(2012)MicroRNA-335 acts as a metastasis suppressor in gastric cancer by targeting Bcl-w and specificity protein 1 Oncogene. 31 1398-2333
[9]  
Mitsuyoshi H(2017)MicroRNA-34a suppresses colorectal cancer metastasis by regulating Notch signaling Oncol. Lett. 14 2325-undefined
[10]  
Yagi N(2015)MicroRNA-141 inhibits tumor growth and metastasis in gastric cancer by directly targeting transcriptional co-activator with PDZ-binding motif TAZ. Cell Death Dis. 6 undefined-undefined
123456789