Chenopodium quinoa ethanolic extract ameliorates cyclophosphamide®-induced hepatotoxicity in male rats

被引：19
作者：
Abdel-Wahhab K.G. [1 ]
Mannaa F.A. [1 ]
Ashry M. [2 ]
Khaled D.M. [3 ]
Hassan L.K. [4 ]
Gomaa H.F. [5 ,6 ]
机构：
[1] Medical Physiology Department, National Research Centre, Giza
[2] Zoology Department, Faculty of Science, Al-Azhar University, Asyut
[3] Histology Department, Faculty of Medicine, Helwan University, Cairo
[4] Dairy Department, National Research Centre, Giza
[5] Biological Sciences Department, Faculty of Sciences and Arts, Scientific Department, Qassium University, Buraydah
[6] Zoology Department, Faculty of Science, Ain Shams University, Cairo
来源：
Comparative Clinical Pathology | 2021年 / 30卷 / 2期
关键词：
Chenopodium quinoa; Cyclophosphamide®; Hepatotoxicity; Rat;
D O I：
10.1007/s00580-021-03199-z
中图分类号：
学科分类号：
摘要：
Cancer is a disease that is associated with abnormal proliferation and growth of living cells, and cyclophosphamide® therapy results in hepatotoxicity. This study aimed to investigate ameliorative effect of Chenopodium quinoa ethanolic extract (QEE) against cyclophosphamide®-induced hepatotoxicity. Four groups (10 male Wistar rats each) were used: (1) healthy control group; (2) rats treated orally with QEE (400 mg/kg/day) for 4 weeks; (3) rats injected intraperitoneally with cyclophosphamide® (150 mg/kg/week) for 4 weeks; (4) rats received QEE after cyclophosphamide® intoxication another 4 weeks. The results revealed that QEE succeeded to decrease the hepatotoxicity-induced by cyclophosphamide®; this was evidenced by the significant reduction in serum ALAT, ASAT, GGT, ALP, total cholesterol, triglycerides, LDL-cholesterol, and TNF-α IL 1β and IL6, as well as hepatic MDA, nitric oxide levels, and DNA fragmentation coupled with a marked rise in serum albumin and HDL-cholesterol level as well as hepatic GSH, SOD, GPx, and catalase values. QEE succeeded also in improving the histopathological picture of the liver. It could be concluded that QEE succeeded, to a great extent, to counteract the oxidative stress and regenerated the liver against cyclophosphamide®-resultant hepatotoxicity. QEE could be considered a promising candidate as a food supplement for the protection against the side effects of cyclophosphamide®. © 2021, The Author(s), under exclusive licence to Springer-Verlag London Ltd. part of Springer Nature.
引用
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页码：267 / 276
页数：9
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