Safety and Biodistribution of Human Bone Marrow-Derived Mesenchymal Stromal Cells Injected Intrathecally in Non-Obese Diabetic Severe Combined Immunodeficiency Mice: Preclinical Study

被引:0
|
作者
Mari Paz Quesada
David García-Bernal
Diego Pastor
Alicia Estirado
Miguel Blanquer
Ana Mª García-Hernández
José M. Moraleda
Salvador Martínez
机构
[1] Campus of International Excellence “Campus Mare Nostrum” University of Murcia,Cellular Therapy and Hematopoietic Transplant Unit, Hematology Department, Virgen de la Arrixaca Clinical University Hospital, Biomedical Research Institute of Murcia, IMIB
[2] University of Murcia,Arrixaca
[3] Virgen de la Arrixaca Clinical University Hospital,Internal Medicine Department, Medicine School
[4] University Miguel Hernández of Elche,Sport Research Center
[5] University Miguel Hernández of Elche,Neuroscience Institute UMH
[6] CIBERSAM-ISCIII,CSIC
[7] University Miguel Hernández of Elche,Human Anatomy Department, Medicine School
关键词
Intrathecal transplantation; Bone marrow-derived mesenchymal stromal cells; Friedreich’s Ataxia; Neuroprotection; Preclinical study;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:525 / 538
页数:13
相关论文
共 50 条
  • [21] Ultrastructural study of cultured ovine bone marrow-derived mesenchymal stromal cells
    Desantis, Salvatore
    Accogli, Gianluca
    Zizza, Sara
    Mastrodonato, Maria
    Blasi, Antonella
    Francioso, Edda
    Rossi, Roberta
    Crovace, Antonio
    Resta, Leonardo
    ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER, 2015, 201 : 43 - 49
  • [22] In vivo bioimaging using photogenic rats:: Fate of injected bone marrow-derived mesenchymal stromal cells
    Hara, Mayumi
    Murakami, Takashi
    Kobayashi, Eiji
    JOURNAL OF AUTOIMMUNITY, 2008, 30 (03) : 163 - 171
  • [23] Endogenous bone morphogenetic proteins in human bone marrow-derived multipotent mesenchymal stromal cells
    Seib, F. Philipp
    Franke, Martina
    Jing, Duohui
    Werner, Carsten
    Bornhaeuser, Martin
    EUROPEAN JOURNAL OF CELL BIOLOGY, 2009, 88 (05) : 257 - 271
  • [24] Expansion of human bone marrow-derived mesenchymal stromal cells with enhanced immunomodulatory properties
    Neo, Shu Hui
    Her, Zhisheng
    Othman, Rashidah
    Tee, Ching Ann
    Ong, Li Ching
    Wang, Yuehua
    Tan, Irwin
    Tan, Jaylen
    Yang, Yanmeng
    Yang, Zheng
    Chen, Qingfeng
    Boyer, Laurie A.
    STEM CELL RESEARCH & THERAPY, 2023, 14 (01)
  • [25] Data on nitric oxide production by human bone marrow-derived mesenchymal stromal cells
    Najar, Mehdi
    Fayyad-Kazan, Mohammad
    Fayyad-Kazan, Hussein
    Meuleman, Nathalie
    Bron, Dominique
    Lagneaux, Laurence
    DATA IN BRIEF, 2016, 8 : 1111 - 1114
  • [26] Expansion of human bone marrow-derived mesenchymal stromal cells with enhanced immunomodulatory properties
    Shu Hui Neo
    Zhisheng Her
    Rashidah Othman
    Ching Ann Tee
    Li Ching Ong
    Yuehua Wang
    Irwin Tan
    Jaylen Tan
    Yanmeng Yang
    Zheng Yang
    Qingfeng Chen
    Laurie A. Boyer
    Stem Cell Research & Therapy, 14
  • [27] Suppression of the IPI3K-Akt pathway is involved in the decreased adhesion and migration of bone marrow-derived mesenchymal stem cells from non-obese diabetic mice
    Li, Liren
    Xia, Yunfei
    Wang, Zhiwei
    Cao, Xiaolei
    Da, Zhanyun
    Guo, Gengkai
    Qian, Jie
    Liu, Xia
    Fan, Yaping
    Sun, Lingyun
    Sang, Aiming
    Gu, Zhifeng
    CELL BIOLOGY INTERNATIONAL, 2011, 35 (09) : 961 - 966
  • [28] ENHANCED TRANSFECTION OF HUMAN BONE MARROW-DERIVED MESENCHYMAL STROMAL CELLS WITH MESSENGER RNA
    Pennati, A.
    Pagenkopf, A. C.
    Kopp, L.
    Galipeau, J.
    CYTOTHERAPY, 2024, 26 (06) : S57 - S58
  • [29] Genetic stability of bone marrow-derived human mesenchymal stromal cells in the Quantum System
    Jones, Mark
    Varella-Garcia, Marileila
    Skokan, Margaret
    Bryce, Steven
    Schowinsky, Jeffrey
    Peters, Rebecca
    Vang, Boah
    Brecheisen, Michelle
    Startz, Thomas
    Frank, Nathan
    Nankervis, Brian
    CYTOTHERAPY, 2013, 15 (11) : 1323 - 1339
  • [30] Comprehensive characterization of bone marrow-derived mesenchymal stromal cells from patients affected by primary immunodeficiency
    Starc, N.
    Ingo, D.
    Conforti, A.
    Rossella, V.
    Tomao, L.
    Redaelli, D.
    Pitisci, A.
    Farinelli, G.
    Algeri, M.
    Palumbo, G.
    Rossi, P.
    Aiuti, A.
    Locatelli, F.
    Bernardo, M. E.
    HUMAN GENE THERAPY, 2016, 27 (11) : A34 - A34