The effect of materials processing- and component manufacturing-induced uncertainties in material properties and component shape and size on the reliability of component performance is investigated. Specifically, reliability of a suspension system component from a high-mobility multipurpose wheeled vehicle which typically can fail under low-cycle strain-based fatigue conditions is analyzed. Toward that end, the most advanced reliability-based design optimization methods available in the literature were combined with the present understanding of low-cycle fatigue durability and applied to the component in question. This entailed intricate integration of several computational tools such as multibody vehicle dynamics, finite-element simulations, and fatigue strain-life assessment/prediction techniques. The results obtained clearly revealed the importance of consideration of material property uncertainties in attaining vehicle performance of critical structural components in complex systems (e.g., a vehicle).