Improving outcomes in difficult bone cancers using multimodality therapy, including radiation: Physician and nursing perspectives

被引：15

作者：

Anderson P. ^{[1
]}

Salazar-Abshire M. ^{[1
]}

机构：

[1] Department of Pediatrics, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030-4009

来源：

Current Oncology Reports | 2006年 / 8卷 / 6期

关键词：

Osteosarcoma; Radiat Oncol Biol Phys; Samarium; Multimodality Therapy; Bone Cancer;

D O I：

10.1007/s11912-006-0069-6

中图分类号：

学科分类号：

摘要：

Principles of therapy are similar for Ewing's sarcoma and osteosarcoma. Chemotherapy or surgery alone cures few patients. Multimodality measures are needed for durable response. Quality of life and function are very important short- and long-term considerations. The spine, sacrum, pelvis, ankle, hand, mediastinum, pulmonary hilum, and chest wall are examples of bone cancer locations for which surgery is difficult. Patients with positive margins may need radiation and may experience systemic therapy delay, recurrence, loss of function, or any combination of these. When radiation is used as a means of local control, concomitant chemotherapy can increase its effectiveness. Options for difficult Ewing's sarcoma and osteosarcoma situations and multimodality solutions, including 1 mCi/kg of samarium and proton therapy, are discussed. Combination radiation and chemotherapy regimens are summarized, and organization of patients, caregivers, and medical teams for multimodality therapy is described, along with tools used in our institution that aid in this process. Copyright © 2006 by Current Science Inc.

引用

页码：415 / 422

页数：7

共 50 条

[1]

Herzog C.E., Overview of sarcomas in the adolescent and young adult population, J Pediatr Hematol Oncol, 27, pp. 215-218, (2005)

[2]

Sharma R., Tobin P., Clarke S.J., Management of chemotherapy-induced nausea, vomiting, oral mucositis, and diarrhoea, Lancet Oncol, 6, pp. 93-102, (2005)

[3]

Cox J.D., Proton beam radiation therapy in the treatment of cancer, Clin Adv Hematol Oncol, 2, pp. 355-356, (2004)

[4]

Lee C.T., Bilton S.D., Famiglietti R.M., Et al., Treatment planning with protons for pediatric retinoblastoma, medulloblastoma, and pelvic sarcoma: How do protons compare with other conformal techniques?, Int J Radiat Oncol Biol Phys, 63, pp. 362-372, (2005)

[5]

Anderson P., Osteosarcoma relapse: Expect the worst, but hope for the best, Pediatr Blood Cancer, 47, (2006)

[6]

Jaffe N., Carrasco H., Raymond K., Et al., Can cure in patients with osteosarcoma be achieved exclusively with chemotherapy and abrogation of surgery?, Cancer, 95, pp. 2202-2210, (2002)

[7]

Machak G.N., Tkachev S.I., Solovyev Y.N., Et al., Neoadjuvant chemotherapy and local radiotherapy for high-grade osteosarcoma of the extremities, Mayo Clin Proc, 78, pp. 147-155, (2003)

[8]

Pritchard D.J., Dahlin D.C., Dauphine R., Et al., Ewing's sarcoma. A clinicopathological and statistical analysis of patients surviving five years or longer, J Bone Joint Surg Am, 57, pp. 10-16, (1975)

[9]

Jaffe N., Metastases in malignant childhood tumors-the role of "adjuvant" therapy and the utility of multidisciplinary treatment, Semin Oncol, 4, pp. 127-177, (1977)

[10]

Nardin A., Lefebvre M.L., Labroquere K., Et al., Liposomal muramyl tripeptide phosphatidylethanolamine: Targeting and activating macrophages for adjuvant treatment of osteosarcoma, Current Cancer Drug Targets, 6, pp. 561-571, (2006)

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