Noradrenergic targets for the treatment of alcohol use disorder

被引：0

作者：

Carolina L. Haass-Koffler

Robert M. Swift

Lorenzo Leggio

机构：

[1] Brown University,Center for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior

[2] Brown University,Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences

[3] National Institute on Alcohol Abuse and Alcoholism and National Institute on Drug Abuse,Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology

[4] National Institutes of Health,undefined

[5] Providence VA Medical Center,undefined

来源：

Psychopharmacology | 2018年 / 235卷

关键词：

Norepinephrine; Alcohol use disorder; Stress;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The role of norepinephrine (NE) in the development of alcohol use disorder (AUD) has been studied over the past several decades. However, the NE system has been largely ignored for many years as a potential target for medication development for AUD. More recently, preclinical and clinical studies have demonstrated the potential value of targeting NE signaling for developing new pharmacological treatments for AUD. This review contributes to a special issue of Psychopharmacology focused on promising targets for alcohol addiction. Specifically, this review coalesces preclinical and clinical neuroscience that re-evaluate the noradrenergic system, and in particular the alpha-1 receptor, as a potential target for AUD.

引用

页码：1625 / 1634

页数：9