Cocaine self-administration selectively abolishes LTD in the core of the nucleus accumbens

被引：0
作者：
Miquel Martin
Billy T Chen
F Woodward Hopf
M Scott Bowers
Antonello Bonci
机构：
[1] Ernest Gallo Clinic and Research Center,Department of Neurology
[2] University of California San Francisco,undefined
[3] Wheeler Center for the Neurobiology of Drug Addiction,undefined
[4] University of California San Francisco,undefined
来源：
Nature Neuroscience | 2006年 / 9卷
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摘要：
The core and shell of the nucleus accumbens have critical, differential roles in drug-dependent behaviors. Here we show that operant cocaine self-administration inhibits long-term depression (LTD) in both structures after 1 d of abstinence. However, after 21 d of abstinence, LTD was abolished exclusively in the nucleus accumbens core of cocaine self-administering rats, suggesting that voluntary cocaine self-administration induced long-lasting neuroadaptations in the core that could underlie drug-seeking behavior and relapse.
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页码：868 / 869
页数：1
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