Effect of salicylate on the large GABAergic neurons in the inferior colliculus of rats

被引：0
作者：
Qiao-Zhi Zou
Xiu-Li Shang
机构：
[1] China Medical University,Department of Neurology, Affiliated First Hospital
来源：
Acta Neurologica Belgica | 2012年 / 112卷
关键词：
Salicylate; GABAergic neurons; VGLUT2; Inhibitory projection;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Salicylate, the anti-inflammatory component of aspirin, induces transient tinnitus and hearing loss in clinical and animal experiments. However, the affected sites and mechanisms of generation remain unclear. Recently, down-regulation of inhibitory transmission mediated by γ-aminobutyric acid type A receptors was suggested to be crucial in generating tinnitus. However, the cell-specific pathways involved in this process were far from being understood. Here, we describe changes of inhibitory neurotransmitter, receptor, and glutamatergic axosomatic terminals in certain large GABAergic neurons (LGNs) in the inferior colliculus of rats treated with high doses of salicylate. Based on these results, we suggest that salicylate may affect inhibitory projection pathways from the inferior colliculus to the auditory cortex and lead to neural hyperactivity, perhaps by affecting the function of the LGNs.
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页码：367 / 374
页数：7
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