Korean red ginseng extract alleviates atherosclerotic lesions in apolipoprotein E knockout mice

被引：0
作者：
Eui-Suk Jeong
Jin-Hee Seo
Ran Ji Yoo
Yong Jin Lee
Joo Hyun Kang
Seung-Yeol Nah
Yang-Kyu Choi
机构：
[1] Konkuk University,Department of Laboratory Animal Medicine, College of Veterinary Medicine
[2] Korea Institute of Radiological & Medical Sciences,Laboratory Animal Facility
[3] Korea Institute of Radiological & Medical Sciences,Molecular Imaging Research Center
[4] Konkuk University,Department of Physiology, College of Veterinary Medicine
来源：
Food Science and Biotechnology | 2014年 / 23卷
关键词：
Korean red ginseng; apolipoprotein E knockout; atherosclerosis; inflammation; therapeutic strategy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This study was to evaluate the anti-atherosclerotic effect of Korean red ginseng (KRG) in apolipoprotein E knockout (ApoE KO) mice. Female ApoE KO mice were divided into 2 groups and were treated via intragastric inoculation for 21 weeks. The body weight increased gradually in both the KRG extract inoculation group and the control group inoculated with saline. Plaque lesion areas in the aortic sinus were reduced largely in the KRG inoculation group than in the control group. Triglyceride and inflammatory cytokines such as monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-α) were significantly reduced in the KRG inoculation group. Additionally, the KRG inoculation group showed significantly lower cardiovascular inflammation by 18F-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography compared to that in the control group. Taken together, KRG alleviates atherosclerotic lesions through MCP-1 and TNF-α suppression. These results suggest that KRG could be a valuable therapeutic strategy for the treatment of atherosclerosis.
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页码：1267 / 1272
页数：5
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