A new triterpene glycoside from the stems of Lagerstroemia indica

被引：0
作者：
Kyeong Wan Woo
Joon Min Cha
Sang Un Choi
Kang Ro Lee
机构：
[1] Sungkyunkwan University,Natural Products Laboratory, School of Pharmacy
[2] Korea Research Institute of Chemical Technology,undefined
来源：
Archives of Pharmacal Research | 2016年 / 39卷
关键词：
Lythraceae; Triterpene glycoside; Cytotoxicity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A bioassay-guided fractionation and chemical investigation of the stems of Lagerstroemia indica resulted in the isolation and identification of a new triterpene glycoside, lagerindiside (1), along with nine known triterpenes (2–10). The structure of this new compound was elucidated on the basis of 1D and 2D nuclear magnetic resonance spectroscopic data analysis as well as chemical method. The cytotoxic activities of the isolates (1–10) were evaluated by determining their inhibitory effects on four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15) using a sulforhodamine B bioassay. Compounds 3 and 4 showed potent cytotoxicity on the tumor cell lines with IC50 values ranging from 3.38 to 6.29 μM.
引用
收藏
页码：631 / 635
页数：4
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