Cucurbitacin C as an effective anti-cancer agent: unveiling its potential role against cholangiocarcinoma and mechanistic insights

[1] Banales JM(2020)Cholangiocarcinoma 2020: the next horizon in mechanisms and management Nat Rev Gastroenterol Hepatol 17 557-588

[2] Marin JJG(2015)Biliary tract cancers: SEOM clinical guidelines Clin Transl Oncol 17 982-987

[3] Lamarca A(2015)Epidemiology of cholangiocarcinoma Best Pract Res Clin Gastroenterol 29 221-232

[4] Rodrigues PM(2018)Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries CA Cancer J Clin 68 394-424

[5] Khan SA(2021)Cholangiocarcinoma Nat Rev Dis Primers 7 65-52

[6] Roberts LR(2010)Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562 Cancer Lett 289 46-2746

[7] Benavides M(2016)Low nanomolar concentrations of Cucurbitacin-I induces G2/M phase arrest and apoptosis by perturbing redox homeostasis in gastric cancer cells in vitro and in vivo Cell Death Dis 7 2735-25

[8] Antón A(2011)Apoptosis induction through proteasome inhibitory activity of cucurbitacin D in human T-cell leukemia Cancer 117 15-255

[9] Gallego J(2014)Inactivation of ATP citrate lyase by Cucurbitacin B: a bioactive compound from cucumber, inhibits prostate cancer growth Cancer Lett 349 239-45

[10] Gómez MA(2018)Desmoplastic tumor microenvironment and immunotherapy in Cholangiocarcinoma Trends Cancer 4 62-15

[1] Banales JM(2020)Cholangiocarcinoma 2020: the next horizon in mechanisms and management Nat Rev Gastroenterol Hepatol 17 557-588

[2] Marin JJG(2015)Biliary tract cancers: SEOM clinical guidelines Clin Transl Oncol 17 982-987

[3] Lamarca A(2015)Epidemiology of cholangiocarcinoma Best Pract Res Clin Gastroenterol 29 221-232

[4] Rodrigues PM(2018)Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries CA Cancer J Clin 68 394-424

[5] Khan SA(2021)Cholangiocarcinoma Nat Rev Dis Primers 7 65-52

[6] Roberts LR(2010)Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562 Cancer Lett 289 46-2746

[7] Benavides M(2016)Low nanomolar concentrations of Cucurbitacin-I induces G2/M phase arrest and apoptosis by perturbing redox homeostasis in gastric cancer cells in vitro and in vivo Cell Death Dis 7 2735-25

[8] Antón A(2011)Apoptosis induction through proteasome inhibitory activity of cucurbitacin D in human T-cell leukemia Cancer 117 15-255

[9] Gallego J(2014)Inactivation of ATP citrate lyase by Cucurbitacin B: a bioactive compound from cucumber, inhibits prostate cancer growth Cancer Lett 349 239-45

[10] Gómez MA(2018)Desmoplastic tumor microenvironment and immunotherapy in Cholangiocarcinoma Trends Cancer 4 62-15