A Rapid Near-Infrared Fluorescent Probe for Cysteine Based on Isophorone and its Application in B16 Cell Imaging

被引：0

作者：

Yan-Ya Wang

Xue-Shuang Yu

Xin-Jie Li

Hong-Bo Liu

Xi Zhu

Ya-Wen Wang

Yu Peng

机构：

[1] Southwest Jiaotong University,School of Life Science and Engineering

[2] The Third People’s Hospital of Chengdu,Department of Neurology

[3] the Affiliated Hospital of Southwest Jiaotong University,undefined

来源：

Journal of Fluorescence | 2022年 / 32卷

关键词：

Biothiols; Near-infrared; Fluorescence probe; Bioimaging; Molecular recognition;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A novel near-infrared fluorescent probe SWJT-5 based on dicyanoisophorone was synthesized. It achieved the rapid (within 40 s) and discriminative detection of Cys over Hcy and GSH with a large Stokes shift (205 nm). It showed high selectivity and sensitivity for Cys, and had an obvious enhancement of fluorescence emission. The detection limit was 0.43 μM. This probe also had low background interference and little damage to biological samples. Therefore, SWJT-5 had been applied to bioimaging in living cells successfully.

引用

页码：1661 / 1667

页数：6

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