A pilot psychometric study of aberrant salience state in patients with Parkinson’s disease and its association with dopamine replacement therapy

被引:0
作者
Michele Poletti
Daniela Frosini
Cristina Pagni
Filippo Baldacci
Claudio Lucetti
Paolo Del Dotto
Roberto Ceravolo
Ubaldo Bonuccelli
机构
[1] AUSL of Reggio Emilia,Department of Mental Health and Pathological Addiction
[2] Neurology Unit,Department of Clinical and Experimental Medicine
[3] University of Pisa,undefined
[4] Neurology Unit,undefined
[5] Versilia Hospital,undefined
[6] USL12 Toscana,undefined
来源
Neurological Sciences | 2014年 / 35卷
关键词
Parkinson’s disease; Aberrant salience; Dopamine overdose; Levodopa; Dopamine agonists; Psychosis;
D O I
暂无
中图分类号
学科分类号
摘要
An overactive striatal dopaminergic neurotransmission is described in psychosis and may be associated with a state of aberrant salience attribution. This pilot psychometric study investigated if features suggestive of an aberrant salience state, a condition of psychosis proneness, are associated with dopamine replacement therapy in patients with early Parkinson’s disease (PD). 77 participants (50 medicated PD patients, 12 newly diagnosed drug-naive PD patients and 15 healthy controls) were enrolled and assessed with the Aberrant Salience Inventory (ASI). Differences between groups were found for ASI scores, and ASI scores correlated with the dopaminergic therapy, in particular levodopa. These findings preliminary suggested that the presence and the degree of an aberrant salience state may be associated with features of the dopaminergic therapy; further studies are needed to investigate which neuropsychiatric complications more common in PD patients may be characterized by an underlying aberrant salience state.
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页码:1603 / 1605
页数:2
相关论文
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