Detection of a Novel Truncated WT1 Transcript in Human Neoplasia

被引：0
|
作者：
Chavaboon Dechsukhum
Joy L. Ware
Andrea Ferreira-Gonzalez
David S. Wilkinson
Carleton T. Garrett
机构：
[1] Medical College of Virginia Campus of Virginia Commonwealth University,Department of Pathology
来源：
Molecular Diagnosis | 2000年 / 5卷 / 2期
关键词：
WT1; prostate cancer; novel transcript;
D O I：
10.1007/BF03262030
中图分类号：
学科分类号：
摘要：
Background: The Wilms’ tumor 1 (WT1) gene encodes a transcription factor critical in urogenital development. Using a new model of prostate cancer progression that permits comparison of the cellular and molecular properties of increasingly aggressive sublines of simian virus 40 large T-antigen—immortalized human prostate epithelial cells within the same lineage, the role of WT1 in tumorigenesis was investigated.
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页码：117 / 128
页数：11
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