The association between HDAC9 gene polymorphisms and stroke risk in the Chinese population: A meta-analysis

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作者
Xin Zhou
Tangming Guan
Shuyuan Li
Zinan Jiao
Xiaoshuang Lu
Xiaodi Huang
Yuhua Ji
Qiuhong Ji
机构
[1] Institute of Immunology,Department of Neurology
[2] College of Life Science and Technology,undefined
[3] Jinan University,undefined
[4] Affiliated Hospital of Guangdong Medical University,undefined
[5] Affiliated Hospital of Nantong University,undefined
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Scientific Reports | / 7卷
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摘要
Several recent genome-wide association studies (GWASs) have suggested that the histone deacetylase 9 (HDAC9) gene is associated with stroke, but the reliability of these findings remains controversial, particularly for the data derived from different ethnicities and geographical locations. Therefore, we performed a meta-analysis to explore the associations between HDAC9 polymorphisms and the risk of stroke in the Chinese population. All eligible case-control studies that met the search criteria were retrieved from multiple databases, and six case-control studies with a total of 2,356 stroke patients and 3,420 healthy controls were included. The pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated to assess the strengths of the associations of 3 HDAC9 gene polymorphisms with stroke risk. Our results revealed statistically significant associations of the rs2107595 (T/C) polymorphism with an increased risk of stroke in the allele, codominant and dominant models. Additionally, the rs2389995 (G/A) polymorphism was found to be significantly associated with a decreased risk of stroke in all genetic models. In conclusion, this meta-analysis suggested that the T allele of rs2107595 in HDAC9 increases the risk of stroke but that the G allele of rs2389995 decreases the risk of stroke in the Chinese population.
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