A model of aluminum exposure associated with lipid peroxidation in rat brain

被引：0
作者：
Yuki Ogasawara
Eri Ohata
Takashi Sakamoto
Kazuyuki Ishii
Hidenobu Takahashi
Shinzo Tanabe
机构：
[1] Meiji Pharmaceutical University,Department of Environmental Biology
[2] Meiji Pharmaceutical University,Department of Analytical Biochemistry
来源：
Biological Trace Element Research | 2003年 / 96卷
关键词：
Aluminum; lipid peroxidation; rat brain; animal model;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We have developed a rat model to investigate the relationship between aluminum exposure and aluminum accumulation, and with oxidative damage in brain tissues. Intraperitoneal injections of aluminum lactate for 7 wk (the total aluminum dosage per rat was approx 100 mg) significantly increased aluminum levels in the brain. The concentration of lipid peroxidation products (thiobarbituric acid-reactive substances [TBARS]) also increased in the brain following aluminum lactate injections. No significant correlations between the concentrations of aluminum and of TBARS were found in the whole brain. Subcellular analysis revealed that aluminum lactate injections led to a significant increase in the concentration of aluminum in the mitochondrial fraction but had no significant effect on the concentration of peroxides in any subcellular fraction.
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页码：191 / 201
页数：10
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