Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease

被引：0
作者：
Mia E.-L. Blomqvist
Peter A. Silburn
Daniel D. Buchanan
Niels Andreasen
Kaj Blennow
Nancy L. Pedersen
Anthony J. Brookes
George D. Mellick
Jonathan A. Prince
机构：
[1] Karolinska Institute,Center for Genomics and Bioinformatics
[2] Princess Alexandra Hospital,Department of Neurology, University of Queensland School of Medicine
[3] Huddinge University Hospital,Neurotec, Department of Geriatric Medicine
[4] Sahlgren’s University Hospital,Department of Clinical Neuroscience and Transfusion Medicine, University of Göteborg
[5] Karolinska Institute,Department of Epidemiology and Biostatistics
[6] Karolinska Institute,Center for Genomics and Bioinformatics
来源：
Neurogenetics | 2004年 / 5卷
关键词：
Age at onset; Linkage disequilibrium; Alzheimer disease; Parkinson disease;
D O I：
暂无
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学科分类号：
摘要：
We recently reported that a linkage disequilibrium (LD) block on chromosome 10q encompassing the gene encoding insulin-degrading enzyme (IDE) harbors sequence variants that associate with Alzheimer disease (AD). Evidence also indicated effects upon a number of quantitative indices of AD severity, including age-at-onset (AAO). Since linkage of this immediate region to AAO has been shown in both AD and Parkinson disease (PD), we have explored the possibility that polymorphism within this LD block might also influence PD. Utilizing single nucleotide polymorphisms that delineate common haplotypes from this region, we observed significant evidence of association with AAO in an Australian PD case-control sample. Analyses were complemented with AAO data from two independent Swedish AD case samples, for which previously reported findings were replicated. Results were consistent between AD and PD, suggesting the presence of equivalent detrimental and protective alleles. These data highlight a genomic region in the proximity of IDE that may contribute to AD and PD in a similar manner.
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页码：115 / 119
页数：4
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