Dual targeting of PD-L1 and PD-L2 by PCED1B-AS1 via sponging hsa-miR-194-5p induces immunosuppression in hepatocellular carcinoma

被引:0
作者
Fei Fan
Keji Chen
Xiaoliang Lu
Aijun Li
Caifeng Liu
Bin Wu
机构
[1] Shanghai Eastern Hepatobiliary Surgery Hospital,Department of The Third Ward of Special Treatment
[2] Shanghai Eastern Hepatobiliary Surgery Hospital,Department of Hepatic Surgery I
来源
Hepatology International | 2021年 / 15卷
关键词
Hepatocellular carcinoma; lncRNA; microRNA; PCED1B-AS1; miR-194-5p; PD-L1; PD-L2; Immune checkpoint; Immunosuppression; Exosome;
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页码:444 / 458
页数:14
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[1]  
Villanueva A(2019)Hepatocellular carcinoma N Engl J Med 380 1450-1462
[2]  
Alves RC(2011)Advanced hepatocellular carcinoma. Review of targeted molecular drugs Ann Hepatol 10 21-27
[3]  
Alves D(2018)Cancer immunotherapy using checkpoint blockade Science 359 1350-1034
[4]  
Guz B(2000)Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation J Exp Med 192 1027-3167
[5]  
Matos C(2019)PD-L1 and PD-L2 expression correlated genes in non-small-cell lung cancer Cancer Commun 3 39-979
[6]  
Viana M(2017)PD-L2 expression in human tumors: relevance to anti-PD-1 therapy in cancer Clin Cancer Res 23 3158-254
[7]  
Harriz M(2009)Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma Clin Cancer Res 15 971-62
[8]  
Ribas A(2017)Overexpression of PD-L1 and PD-L2 Is associated with poor prognosis in patients with hepatocellular carcinoma Cancer Res Treat 49 246-369
[9]  
Wolchok JD(2019)Correlation between PD-L2 expression and clinical outcome in solid cancer patients: a meta-analysis Front Oncol 13 9-339
[10]  
Freeman GJ(2016)Unique features of long non-coding RNA biogenesis and function Nat Rev Genet 17 47-1853