Targeting of BMI-1 with PTC-209 shows potent anti-myeloma activity and impairs the tumour microenvironment

[1] Palumbo A(2011)Multiple myeloma N Engl J Med 364 1046-1060

[2] Anderson K(2014)Continued improvement in survival in multiple myeloma: changes in early mortality and outcomes in older patients Leukemia 28 1122-1128

[3] Kumar SK(2011)BMI1 as a novel target for drug discovery in cancer J Cell Biochem 112 2729-2741

[4] Dispenzieri A(1991)Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice Cell 65 753-763

[5] Lacy MQ(1993)bmi-1 transgene induces lymphomas and collaborates with myc in tumorigenesis Oncogene 8 3161-3164

[6] Gertz MA(2005)Association of BMI1 with polycomb bodies is dynamic and requires PRC2/EZH2 and the maintenance DNA methyltransferase DNMT1 Mol Cell Biol 25 11047-11058

[7] Buadi FK(2005)Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing Mol Cell 20 845-854

[8] Pandey S(2006)Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells Cancer Res 66 6225-6232

[9] Cao L(2008)Increased polycomb-group oncogene Bmi-1 expression correlates with poor prognosis in hepatocellular carcinoma J Cancer Res Clin Oncol 134 535-541

[10] Bombard J(2012)Overexpression of BMI-1 is associated with poor prognosis in cervical cancer Asia Pac J Clin Oncol 8 e55-e62

[1] Palumbo A(2011)Multiple myeloma N Engl J Med 364 1046-1060

[2] Anderson K(2014)Continued improvement in survival in multiple myeloma: changes in early mortality and outcomes in older patients Leukemia 28 1122-1128

[3] Kumar SK(2011)BMI1 as a novel target for drug discovery in cancer J Cell Biochem 112 2729-2741

[4] Dispenzieri A(1991)Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice Cell 65 753-763

[5] Lacy MQ(1993)bmi-1 transgene induces lymphomas and collaborates with myc in tumorigenesis Oncogene 8 3161-3164

[6] Gertz MA(2005)Association of BMI1 with polycomb bodies is dynamic and requires PRC2/EZH2 and the maintenance DNA methyltransferase DNMT1 Mol Cell Biol 25 11047-11058

[7] Buadi FK(2005)Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing Mol Cell 20 845-854

[8] Pandey S(2006)Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells Cancer Res 66 6225-6232

[9] Cao L(2008)Increased polycomb-group oncogene Bmi-1 expression correlates with poor prognosis in hepatocellular carcinoma J Cancer Res Clin Oncol 134 535-541

[10] Bombard J(2012)Overexpression of BMI-1 is associated with poor prognosis in cervical cancer Asia Pac J Clin Oncol 8 e55-e62