Minimally invasive implantable fetal micropacemaker: mechanical testing and technical refinements

被引：0
|
作者：
Li Zhou
Adriana Nicholson Vest
Raymond A. Peck
Jonathan P. Sredl
Xuechen Huang
Yaniv Bar-Cohen
Michael J. Silka
Jay D. Pruetz
Ramen H. Chmait
Gerald E. Loeb
机构：
[1] University of Southern California,Medical Device Development Facility, Department of Biomedical Engineering, Viterbi School of Engineering
[2] Children’s Hospital of Los Angeles,Division of Cardiology, Department of Pediatrics
[3] University of Southern California,Keck School of Medicine
[4] University of Southern California,Division of Maternal
来源：
Medical & Biological Engineering & Computing | 2016年 / 54卷
关键词：
Pacemaker; Epicardial; Fetal; Heart block; Hydrops fetalis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This paper discusses the technical and safety requirements for cardiac pacing of a human fetus with heart failure and hydrops fetalis secondary to complete heart block. Engineering strategies to meet specific technical requirements were integrated into a systematic design and implementation consisting of a novel fetal micropacemaker, a percutaneous implantation system, and a sterile package that enables device storage and recharging maintenance in a clinical setting. We further analyzed observed problems on myocardial fixation and pacing lead fatigue previously reported in earlier preclinical trials. This paper describes the technical refinements of the implantable fetal micropacemaker to overcome these challenges. The mechanical performance has been extensively tested to verify the improvement of reliability and safety margins of the implantation system.
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页码：1819 / 1830
页数：11
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