Water-soluble proteins as an excipient for drug administration by inhalation

被引：0
作者：
A. E. Boldyrev
M. A. Ziganshin
N. M. Lyadov
A. E. Klimovitskii
A. V. Gerasimov
机构：
[1] Kazan (Volga Region) Federal University,E. K. Zavoisky Physical Technical Institute
[2] A. M. Butlerov Chemical Institute,undefined
[3] Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences,undefined
[4] ”,undefined
来源：
Russian Chemical Bulletin | 2020年 / 69卷
关键词：
bovine serum albumin; lysozyme; spray drying; microparticles; dissolution;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Microspherical particles of composite drugs based on lysozyme and albumin, which can be used in inhalation administration, were prepared by spray drying. The composition of the complexes was determined using experimental and theoretical methods. The use of the protein matrix makes it possible to increase the dissolution rate of the drug in water. The obtained results can be useful for the development of new drug dosage forms with increased bioavailability.
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页码：608 / 614
页数：6
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