Myelomeningocele in an infant with intrauterine exposure to efavirenz

被引：39

作者：

Saitoh A. ^{[1
]}

Hull A.D. ^{[2
]}

Franklin P. ^{[1
]}

Spector S.A. ^{[1
]}

机构：

[1] Division of Infectious Diseases, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093-0672

[2] Department of Reproductive Medicine, University of California San Diego, La Jolla, CA 92093-0672

来源：

Journal of Perinatology | 2005年 / 25卷 / 8期

关键词：

D O I：

10.1038/sj.jp.7211343

中图分类号：

学科分类号：

摘要：

We report a case of myelomeningocele in an infant whose mother was exposed to efavirenz during the first 16 weeks of pregnancy. Although the true risk for myelomeningocele with the use of efavirenz early in pregnancy is still unknown, the findings in humans are consistent with those observed in primates and suggest that efavirenz is a potent teratogen. Thus, we suggest that efavirenz only be prescribed for women of childbearing potential when no other comparable antiretroviral options are available. © 2005 Nature Publishing Group. All rights reserved.

引用

页码：555 / 556

页数：1

共 8 条

[1] Gulick R.M., Ribaudo H.J., Shikuma C.M., Et al., Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection, N. Engl. J. Med., 350, pp. 1850-1861, (2004)
[2] Staszewski S., Morales-Ramirez J., Tashima K.T., Et al., Efavirenz plus zidovudine and lamivudine, efavirenz plus indinavir, and indinavir plus zidovudine and lamivudine in the treatment of HIV-1 infection in adults, N. Engl. J. Med., 341, pp. 1865-1873, (1999)
[3] Recommendations for use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal HIV-1 transmission in the United States, (2005)
[4] Nightingale S.L., From the food and drug administration, JAMA, 280, (1998)
[5] Fundaro C., Genovese O., Rendeli C., Tamburrini E., Salvaggio E., Myelomeningocele in a child with intrauterine exposure to efavirenz, AIDS, 16, pp. 299-300, (2002)
[6] De Santis M., Carducci B., De Santis L., Cavaliere A.F., Straface G., Periconceptional exposure to efavirenz and neural tube defects, Arch. Intern. Med., 162, (2002)
[7] Antiretroviral Pregnancy Registry International Interim Report for January 1989 through 31 January 2004, (2004)
[8] Botto L.D., Moore C.A., Khoury M.J., Erickson J.D., Neural-tube defects, N. Engl. J. Med., 341, pp. 1509-1609, (1999)

← 1 →