Age-Related Changes of NADPH-Diaphorase Positivity in the Rat Rostral Migratory Stream

被引：0
|
作者：
Enikö Račeková
Marcela Martončíková
Barbora Mitrušková
Dáša Čížková
Judita Orendáčová
机构：
[1] Slovak Academy of Sciences Košice,Institute of Neurobiology
[2] Institute of Neurobiology SAS,undefined
来源：
Cellular and Molecular Neurobiology | 2005年 / 25卷
关键词：
rostral migratory stream; NADPH-diaphorase; neonatal; adult; aging;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Accumulating evidence confirms that nitric oxide (NO), a versatile diffusible signaling molecule, contributes to controling of adult neurogenesis. We have previously shown the timing of NADPH-diaphorase (NADPH-d) positivity within the rat rostral migratory stream (RMS) during the first postnatal month. The present study was designed to describe further age-related changes of NO presence in this neurogenic region. The presence of NO synthesizing cells in the RMS was shown by NADPH-d histochemistry and neuronal nitric oxide synthase (nNOS) immunohistochemistry. The phenotypic identity of nitrergic cells was examined by double labeling with GFAP and NeuN. Systematic qualitative and quantitative analysis of NADPH-d-positive cells was performed in the neonatal (P14), adult(5 months) and aging (20 months) rat RMS.
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页码：1093 / 1105
页数：12
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