Characterization of a murine model of endothelial dysfunction induced by chronic intraperitoneal administration of angiotensin II

被引：0

作者：

Celeste Trejo-Moreno

Enrique Jiménez-Ferrer

Gabriela Castro-Martínez

Marisol Méndez-Martínez

María Angélica Santana

Gerardo Arrellín-Rosas

José Pedraza-Chaverri

Omar Noel Medina-Campos

Beatriz Hernández-Téllez

Oscar Ramírez-Pliego

Maribel Herrera-Ruiz

Jacquelynne Cervantes-Torres

Zimri Aziel Alvarado-Ojeda

Alejandro Costet-Mejía

Gladis Fragoso

Gabriela Rosas-Salgado

机构：

[1] Universidad Autónoma del Estado de Morelos,Facultad de Medicina

[2] Instituto Mexicano del Seguro Social,Centro de Investigación Biomédica del Sur

[3] Universidad Autónoma Metropolitana-Xochimilco,Departamento de Sistemas Biológicos

[4] Universidad Autónoma del Estado de Morelos,Centro de Investigación en Dinámica Celular

[5] Universidad Panamericana,Facultad de Ciencias de la Salud

[6] Universidad Nacional Autónoma de México,Facultad de Química

[7] Universidad Nacional Autónoma de México,Facultad de Medicina

[8] Universidad Nacional Autónoma de México,Instituto de Investigaciones Biomédicas

[9] Universidad Autónoma Metropolitana-Iztapalapa,Posgrado en Biología Experimental

来源：

Scientific Reports | / 11卷

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摘要：

Endothelial dysfunction (ED) is a key factor for the development of cardiovascular diseases. Due to its chronic, life-threatening nature, ED only can be studied experimentally in animal models. Therefore, this work was aimed to characterize a murine model of ED induced by a daily intraperitoneal administration of angiotensin II (AGII) for 10 weeks. Oxidative stress, inflammation, vascular remodeling, hypertension, and damage to various target organs were evaluated in treated animals. The results indicated that a chronic intraperitoneal administration of AGII increases the production of systemic soluble VCAM, ROS and ICAM-1 expression, and the production of TNFα, IL1β, IL17A, IL4, TGFβ, and IL10 in the kidney, as well as blood pressure levels; it also promotes vascular remodeling and induces non-alcoholic fatty liver disease, glomerulosclerosis, and proliferative retinopathy. Therefore, the model herein proposed can be a representative model for ED; additionally, it is easy to implement, safe, rapid, and inexpensive.

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