Decreased endothelial nitric oxide (NO) bioavailability as it relates to endothelial dysfunction plays an important role in various cardiovascular disorders, including atherosclerosis. Recent research has provided evidence that endothelial dysfunction in atherosclerosis is not primarily caused by decreased endothelial NO synthase (eNOS) gene expression, but rather deregulation of eNOS enzymatic activity, which contributes to the increased oxidative stress in atherosclerosis. Among other mechanisms, the substrate L-arginine is an important limiting factor for NO production. Emerging evidence demonstrates that L-arginine is not only converted to NO via eNOS, but also metabolized to urea and L-ornithine via arginase in endothelial cells. Hence, arginase competes with eNOS for the substrate L-arginine, resulting in deceased NO production. There are an increasing number of studies showing that enhanced arginase gene expression and/or activity contribute to endothelial dysfunction in various cardiovascular disorders, including atherosclerosis. Thus, endothelial arginase may represent a new therapeutic target in atherosclerosis.
机构:
Xinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R ChinaXinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R China
Lu, Jun-X.
Guo, Chao
论文数: 0引用数: 0
h-index: 0
机构:
Xinxiang Med Univ, Coll Pharm, Dept Clin Pharmacol, Xinxiang, Peoples R ChinaXinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R China
Guo, Chao
Ou, Wen-S.
论文数: 0引用数: 0
h-index: 0
机构:
Chenzhou 1 Peoples Hosp, Dept Gastroenterol, Chenzhou, Peoples R ChinaXinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R China
Ou, Wen-S.
Jing, Yun
论文数: 0引用数: 0
h-index: 0
机构:
Xinxiang Med Univ, Coll Pharm, Dept Clin Pharmacol, Xinxiang, Peoples R ChinaXinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R China
Jing, Yun
Niu, Hui-F.
论文数: 0引用数: 0
h-index: 0
机构:
Xinxiang Med Univ, Coll Pharm, Dept Clin Pharmacol, Xinxiang, Peoples R ChinaXinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R China
Niu, Hui-F.
Song, Ping
论文数: 0引用数: 0
h-index: 0
机构:
Xinxiang Med Univ, Coll Pharm, Dept Clin Pharmacol, Xinxiang, Peoples R ChinaXinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R China
Song, Ping
Li, Quan-Z.
论文数: 0引用数: 0
h-index: 0
机构:
Guilin Med Univ, Affiliated Hosp, Dept Cardiol, Guilin, Peoples R ChinaXinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R China
Li, Quan-Z.
Liu, Zhan
论文数: 0引用数: 0
h-index: 0
机构:
Hunan Normal Univ, Affiliated Hosp, Dept Clin Nutr, Changsha, Hunan, Peoples R ChinaXinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R China
Liu, Zhan
Xu, Jian
论文数: 0引用数: 0
h-index: 0
机构:
Xinxiang Med Univ, Coll Pharm, Dept Clin Pharmacol, Xinxiang, Peoples R ChinaXinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R China
Xu, Jian
Li, Peng
论文数: 0引用数: 0
h-index: 0
机构:
Xinxiang Med Univ, Coll Pharm, Dept Clin Pharmacol, Xinxiang, Peoples R ChinaXinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R China
Li, Peng
Zhu, Mo-L.
论文数: 0引用数: 0
h-index: 0
机构:
Xinxiang Med Univ, Coll Pharm, Dept Clin Pharmacol, Xinxiang, Peoples R ChinaXinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R China
Zhu, Mo-L.
Yin, Ya-L.
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h-index: 0
机构:
Xinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R ChinaXinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R China
机构:
Augusta Univ, Dept Pharmacol & Toxicol, Augusta, GA 30912 USA
Augusta Univ, Culver Vis Discovery Inst, Augusta, GA 30912 USAUniv Jordan, Sch Med, Dept Physiol & Biochem, Amman 11942, Jordan
Caldwell, R. William
Caldwell, Ruth B.
论文数: 0引用数: 0
h-index: 0
机构:
Augusta Univ, Culver Vis Discovery Inst, Augusta, GA 30912 USA
Augusta Univ, Med Coll Georgia, Dept Cellular Biol & Anat, Augusta, GA 30912 USA
Augusta Univ, Vasc Biol Ctr, Augusta, GA 30912 USAUniv Jordan, Sch Med, Dept Physiol & Biochem, Amman 11942, Jordan
机构:
Symbiosis Int Deemed Univ, Symbiosis Med Coll Women, Pune, Maharashtra, IndiaSymbiosis Int Deemed Univ, Symbiosis Med Coll Women, Pune, Maharashtra, India
Abhang, Subodhini
Shelgikar, Prachi
论文数: 0引用数: 0
h-index: 0
机构:
Symbiosis Int Deemed Univ, Symbiosis Med Coll Women, Pune, Maharashtra, IndiaSymbiosis Int Deemed Univ, Symbiosis Med Coll Women, Pune, Maharashtra, India
Shelgikar, Prachi
Mulgund, Shruti
论文数: 0引用数: 0
h-index: 0
机构:
Symbiosis Int Deemed Univ, Symbiosis Med Coll Women, Pune, Maharashtra, IndiaSymbiosis Int Deemed Univ, Symbiosis Med Coll Women, Pune, Maharashtra, India
机构:
Univ Texas Hlth Sci Ctr San Antonio, Div Trauma & Emergency Surg, Dept Surg, San Antonio, TX 78229 USA
Natl Trauma Inst, San Antonio, TX USAUniv Texas Hlth Sci Ctr San Antonio, Div Trauma & Emergency Surg, Dept Surg, San Antonio, TX 78229 USA
Johnson, Robert A.
Durante, William
论文数: 0引用数: 0
h-index: 0
机构:
Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO USAUniv Texas Hlth Sci Ctr San Antonio, Div Trauma & Emergency Surg, Dept Surg, San Antonio, TX 78229 USA
Durante, William
Craig, Teresa
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Hlth Sci Ctr San Antonio, Div Trauma & Emergency Surg, Dept Surg, San Antonio, TX 78229 USAUniv Texas Hlth Sci Ctr San Antonio, Div Trauma & Emergency Surg, Dept Surg, San Antonio, TX 78229 USA
Craig, Teresa
Peyton, Kelly J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO USAUniv Texas Hlth Sci Ctr San Antonio, Div Trauma & Emergency Surg, Dept Surg, San Antonio, TX 78229 USA
Peyton, Kelly J.
Myers, John G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Hlth Sci Ctr San Antonio, Div Trauma & Emergency Surg, Dept Surg, San Antonio, TX 78229 USA
Natl Trauma Inst, San Antonio, TX USAUniv Texas Hlth Sci Ctr San Antonio, Div Trauma & Emergency Surg, Dept Surg, San Antonio, TX 78229 USA
Myers, John G.
Stewart, Ronald M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Hlth Sci Ctr San Antonio, Div Trauma & Emergency Surg, Dept Surg, San Antonio, TX 78229 USA
Natl Trauma Inst, San Antonio, TX USAUniv Texas Hlth Sci Ctr San Antonio, Div Trauma & Emergency Surg, Dept Surg, San Antonio, TX 78229 USA
Stewart, Ronald M.
Johnson, Fruzsina K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Hlth Sci Ctr San Antonio, Div Trauma & Emergency Surg, Dept Surg, San Antonio, TX 78229 USA
Natl Trauma Inst, San Antonio, TX USAUniv Texas Hlth Sci Ctr San Antonio, Div Trauma & Emergency Surg, Dept Surg, San Antonio, TX 78229 USA
Johnson, Fruzsina K.
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE,
2010,
69
(02):
: 384
-
391
机构:
Xinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R ChinaXinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R China
Lu, Jun-X.
Guo, Chao
论文数: 0引用数: 0
h-index: 0
机构:
Xinxiang Med Univ, Coll Pharm, Dept Clin Pharmacol, Xinxiang, Peoples R ChinaXinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R China
Guo, Chao
Ou, Wen-S.
论文数: 0引用数: 0
h-index: 0
机构:
Chenzhou 1 Peoples Hosp, Dept Gastroenterol, Chenzhou, Peoples R ChinaXinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R China
Ou, Wen-S.
Jing, Yun
论文数: 0引用数: 0
h-index: 0
机构:
Xinxiang Med Univ, Coll Pharm, Dept Clin Pharmacol, Xinxiang, Peoples R ChinaXinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R China
Jing, Yun
Niu, Hui-F.
论文数: 0引用数: 0
h-index: 0
机构:
Xinxiang Med Univ, Coll Pharm, Dept Clin Pharmacol, Xinxiang, Peoples R ChinaXinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R China
Niu, Hui-F.
Song, Ping
论文数: 0引用数: 0
h-index: 0
机构:
Xinxiang Med Univ, Coll Pharm, Dept Clin Pharmacol, Xinxiang, Peoples R ChinaXinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R China
Song, Ping
Li, Quan-Z.
论文数: 0引用数: 0
h-index: 0
机构:
Guilin Med Univ, Affiliated Hosp, Dept Cardiol, Guilin, Peoples R ChinaXinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R China
Li, Quan-Z.
Liu, Zhan
论文数: 0引用数: 0
h-index: 0
机构:
Hunan Normal Univ, Affiliated Hosp, Dept Clin Nutr, Changsha, Hunan, Peoples R ChinaXinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R China
Liu, Zhan
Xu, Jian
论文数: 0引用数: 0
h-index: 0
机构:
Xinxiang Med Univ, Coll Pharm, Dept Clin Pharmacol, Xinxiang, Peoples R ChinaXinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R China
Xu, Jian
Li, Peng
论文数: 0引用数: 0
h-index: 0
机构:
Xinxiang Med Univ, Coll Pharm, Dept Clin Pharmacol, Xinxiang, Peoples R ChinaXinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R China
Li, Peng
Zhu, Mo-L.
论文数: 0引用数: 0
h-index: 0
机构:
Xinxiang Med Univ, Coll Pharm, Dept Clin Pharmacol, Xinxiang, Peoples R ChinaXinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R China
Zhu, Mo-L.
Yin, Ya-L.
论文数: 0引用数: 0
h-index: 0
机构:
Xinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R ChinaXinxiang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Xinxiang, Peoples R China
机构:
Augusta Univ, Dept Pharmacol & Toxicol, Augusta, GA 30912 USA
Augusta Univ, Culver Vis Discovery Inst, Augusta, GA 30912 USAUniv Jordan, Sch Med, Dept Physiol & Biochem, Amman 11942, Jordan
Caldwell, R. William
Caldwell, Ruth B.
论文数: 0引用数: 0
h-index: 0
机构:
Augusta Univ, Culver Vis Discovery Inst, Augusta, GA 30912 USA
Augusta Univ, Med Coll Georgia, Dept Cellular Biol & Anat, Augusta, GA 30912 USA
Augusta Univ, Vasc Biol Ctr, Augusta, GA 30912 USAUniv Jordan, Sch Med, Dept Physiol & Biochem, Amman 11942, Jordan
机构:
Symbiosis Int Deemed Univ, Symbiosis Med Coll Women, Pune, Maharashtra, IndiaSymbiosis Int Deemed Univ, Symbiosis Med Coll Women, Pune, Maharashtra, India
Abhang, Subodhini
Shelgikar, Prachi
论文数: 0引用数: 0
h-index: 0
机构:
Symbiosis Int Deemed Univ, Symbiosis Med Coll Women, Pune, Maharashtra, IndiaSymbiosis Int Deemed Univ, Symbiosis Med Coll Women, Pune, Maharashtra, India
Shelgikar, Prachi
Mulgund, Shruti
论文数: 0引用数: 0
h-index: 0
机构:
Symbiosis Int Deemed Univ, Symbiosis Med Coll Women, Pune, Maharashtra, IndiaSymbiosis Int Deemed Univ, Symbiosis Med Coll Women, Pune, Maharashtra, India
机构:
Univ Texas Hlth Sci Ctr San Antonio, Div Trauma & Emergency Surg, Dept Surg, San Antonio, TX 78229 USA
Natl Trauma Inst, San Antonio, TX USAUniv Texas Hlth Sci Ctr San Antonio, Div Trauma & Emergency Surg, Dept Surg, San Antonio, TX 78229 USA
Johnson, Robert A.
Durante, William
论文数: 0引用数: 0
h-index: 0
机构:
Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO USAUniv Texas Hlth Sci Ctr San Antonio, Div Trauma & Emergency Surg, Dept Surg, San Antonio, TX 78229 USA
Durante, William
Craig, Teresa
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Hlth Sci Ctr San Antonio, Div Trauma & Emergency Surg, Dept Surg, San Antonio, TX 78229 USAUniv Texas Hlth Sci Ctr San Antonio, Div Trauma & Emergency Surg, Dept Surg, San Antonio, TX 78229 USA
Craig, Teresa
Peyton, Kelly J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO USAUniv Texas Hlth Sci Ctr San Antonio, Div Trauma & Emergency Surg, Dept Surg, San Antonio, TX 78229 USA
Peyton, Kelly J.
Myers, John G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Hlth Sci Ctr San Antonio, Div Trauma & Emergency Surg, Dept Surg, San Antonio, TX 78229 USA
Natl Trauma Inst, San Antonio, TX USAUniv Texas Hlth Sci Ctr San Antonio, Div Trauma & Emergency Surg, Dept Surg, San Antonio, TX 78229 USA
Myers, John G.
Stewart, Ronald M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Hlth Sci Ctr San Antonio, Div Trauma & Emergency Surg, Dept Surg, San Antonio, TX 78229 USA
Natl Trauma Inst, San Antonio, TX USAUniv Texas Hlth Sci Ctr San Antonio, Div Trauma & Emergency Surg, Dept Surg, San Antonio, TX 78229 USA
Stewart, Ronald M.
Johnson, Fruzsina K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Hlth Sci Ctr San Antonio, Div Trauma & Emergency Surg, Dept Surg, San Antonio, TX 78229 USA
Natl Trauma Inst, San Antonio, TX USAUniv Texas Hlth Sci Ctr San Antonio, Div Trauma & Emergency Surg, Dept Surg, San Antonio, TX 78229 USA
Johnson, Fruzsina K.
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE,
2010,
69
(02):
: 384
-
391