Crystal structure of the endogenous agonist-bound prostanoid receptor EP3

被引：0

作者：

Kazushi Morimoto

Ryoji Suno

Yunhong Hotta

Keitaro Yamashita

Kunio Hirata

Masaki Yamamoto

Shuh Narumiya

So Iwata

Takuya Kobayashi

机构：

[1] Kyoto University,Department of Cell Biology, Graduate School of Medicine

[2] Konoe-cho,Japan Agency for Medical Research and Development (AMED)

[3] Yoshida,Medical Innovation Center, Graduate School of Medicine

[4] Core Research for Evolutional Science and Technology (CREST),Department of Medical Chemistry

[5] RIKEN SPring-8 Center,undefined

[6] Sayo-cho,undefined

[7] Kyoto University,undefined

[8] Kansai Medical University,undefined

来源：

Nature Chemical Biology | 2019年 / 15卷

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摘要：

Prostanoids are a series of bioactive lipid metabolites that function in an autacoid manner via activation of cognate G-protein-coupled receptors (GPCRs). Here, we report the crystal structure of human prostaglandin (PG) E receptor subtype EP3 bound to endogenous ligand PGE2 at 2.90 Å resolution. The structure reveals important insights into the activation mechanism of prostanoid receptors and provides a molecular basis for the binding modes of endogenous ligands.

引用

页码：8 / 10

页数：2

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