Correlation of RET somatic mutations with clinicopathological features in sporadic medullary thyroid carcinomas

被引：0

作者：

M M Moura

B M Cavaco

A E Pinto

R Domingues

J R Santos

M O Cid

M J Bugalho

V Leite

机构：

[1] Centro de Investigação de Patobiologia Molecular (CIPM),

[2] Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E.,undefined

[3] Rua Prof. Lima Basto,undefined

[4] Serviço de Anatomia Patológica,undefined

[5] Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E.,undefined

[6] Rua Prof. Lima Basto,undefined

[7] Serviço de Cirurgia Cabeça e Pescoço,undefined

[8] Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E.,undefined

[9] Rua Prof. Lima Basto,undefined

[10] Serviço de Endocrinologia,undefined

[11] Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E.,undefined

[12] Rua Prof. Lima Basto,undefined

[13] Faculdade de Ciências Médicas,undefined

[14] Universidade Nova de Lisboa,undefined

[15] Campo Mártires da Pátria 130,undefined

来源：

British Journal of Cancer | 2009年 / 100卷

关键词：

sporadic medullary thyroid carcinoma; proto-oncogene; somatic mutation; genetic screening; prognosis;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Screening of REarranged during Transfection (RET) gene mutations has been carried out in different series of sporadic medullary thyroid carcinomas (MTC). RET-positive tumours seem to be associated to a worse clinical outcome. However, the correlation between the type of RET mutation and the patients' clinicopathological data has not been evaluated yet.

引用

页码：1777 / 1783

页数：6

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