Advances in understanding the genetic basis of diabetic kidney disease

被引：0
作者：
Man Li
Marcus G. Pezzolesi
机构：
[1] University of Utah School of Medicine,Division of Nephrology and Hypertension, Department of Internal Medicine,
[2] VA Cooperative Studies Program,VA Boston Healthcare System
[3] University of Utah School of Medicine,Diabetes and Metabolism Center
[4] University of Utah School of Medicine,Department of Human Genetics
来源：
Acta Diabetologica | 2018年 / 55卷
关键词：
Diabetic kidney disease; Diabetic nephropathy; Genetics; Genome-wide association study;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Diabetic kidney disease (DKD) is a devastating complication of Type 1 and Type 2 diabetes and leads to increased morbidity and mortality. Earlier work in families has provided strong evidence that heredity is a major determinant of DKD. Previous linkage analyses and candidate gene studies have identified potential DKD genes; however, such approaches have largely been unsuccessful. Genome-wide association studies (GWAS) have made significant contribution in identifying SNPs associated with common complex diseases. Thanks to advanced technology, new analytical approaches, and international research collaborations, many DKD GWASs have reported unique genes, highlighted novel biological pathways and suggested new disease mechanisms. This review summarizes the current state of GWAS technology; findings from GWASs of DKD and its related traits conducted over the past 15 years and discuss the future of this field.
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页码：1093 / 1104
页数：11
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