Antioxidant Enzyme Activities Following Acute or Chronic Methylphenidate Treatment in Young Rats

被引：0
作者：
Karin M. Gomes
Fabrícia C. Petronilho
Mariane Mantovani
Thereza Garbelotto
Carina R. Boeck
Felipe Dal-Pizzol
João Quevedo
机构：
[1] Universidade do Extremo Sul Catarinense,Laboratório de Neurociências, Programa de Pós
[2] Universidade do Extremo Sul Catarinense,Graduação em Ciências da Saúde (PPGCS)
来源：
Neurochemical Research | 2008年 / 33卷
关键词：
Methylphenidate; Superoxide dismutase; Catalase;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Methylphenidate (MPH) is psychostimulants used to treat Attention-Deficit/Hyperactivity Disorder and can lead to a long-lasting neurochemical and behavioral adaptations in experimental animals. In the present study, the cerebral antioxidant enzymatic system, superoxide dismutase (SOD) and catalase (CAT) was evaluated at in different age following MPH (1, 2 or 10 mg/kg MPH, i.p.) treatment in young rats. In the acute treatment the SOD activity decreased in the cerebral prefrontal cortex with opposite effect in the cerebral cortex; and the CAT activity decreased in hippocampus. In the chronic treatment the SOD activity increased in the hippocampus and cerebral cortex and decreased in the striatum. The observed changes on the enzyme activities in rat brain were dependent on the structure brain region and duration of treatment with MPH. Probably, the activity of enzymes was not be enough to prevent MPH-induced oxidative damage in specific regions from brain, such as observed for us in another recent study.
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页码：1024 / 1027
页数：3
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