LncRNA as potential biomarker and therapeutic target in glioma

被引：0
作者：
Xun Xu
Yuan Liang
Ilgiz Gareev
Yanchao Liang
Rui Liu
Ning Wang
Guang Yang
机构：
[1] The First Affiliated Hospital of Harbin Medical University,Department of Neurosurgery
[2] Harbin Medical University,Institute of Brain Science
[3] Xuzhou Third People’s Hospital,Department of Neurosurgery
[4] Bashkir State Medical University,undefined
来源：
Molecular Biology Reports | 2023年 / 50卷
关键词：
Long noncoding RNA; Glioma; Biomarker; Therapeutic target;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Glioma is the most frequent type of malignant tumor in the central nervous system, accounting for about 80% of primary malignant brain tumors, usually with a poor prognosis. A number of studies have been conducted on the molecular abnormalities in glioma to further understand its pathogenesis, and it has been found that lncRNAs (long non-coding RNA) play a key role in angiogenesis, tumor growth, infiltration and metastasis of glioma. Since specific lncRNAs have an aberrant expression in brain tissue, cerebrospinal fluid as well as peripheral circulation of glioma patients, they are considered to be potential biomarkers. This review focuses on the biological characteristics of lncRNA and its value as a biomarker for glioma diagnosis and prognosis. Moreover, in view of the role of lncRNAs in glioma proliferation and chemoradiotherapy resistance, we discussed the feasibility for lncRNAs as therapeutic targets. Finally, the persisting deficiencies and future prospects of using lncRNAs as clinical biomarkers and therapeutic targets were concluded.
引用
收藏
页码：841 / 851
页数：10
相关论文
共 136 条
[1]  
Ohgaki H(2005)Epidemiology and etiology of gliomas Acta Neuropathol 109 93-108
[2]  
Kleihues P(2016)The 2016 world health organization classification of tumors of the central nervous system: a summary Acta Neuropathol 131 803-820
[3]  
Louis DN(2009)Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma J Clin Oncol 27 579-584
[4]  
Prados MD(2015)Circulating glioma biomarkers Neuro Oncol 17 343-360
[5]  
Kros JM(2014)Regulation of transcription by long noncoding RNAs Annu Rev Genet 48 433-455
[6]  
Bonasio R(2011)Molecular mechanisms of long noncoding RNAs Mol Cell 43 904-914
[7]  
Shiekhattar R(2009)Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals Nature 458 223-227
[8]  
Wang KC(2007)A chromatin landmark and transcription initiation at most promoters in human cells Cell 130 77-88
[9]  
Chang HY(2014)The multilayered complexity of ceRNA crosstalk and competition Nature 505 344-352
[10]  
Guttman M(2010)Molecular signals of epigenetic states Science 330 612-616
12345678910