A consideration of CYP2D6 genetic variations in the Ghanaian population as a potential ‘culprit’ for the tramadol ‘abuse crisis’

被引:0
作者
Nicholas Ekow Thomford
Susanna Aba Abraham
Samuel Badu Nyarko
Robert Peter Biney
机构
[1] University of Cape Coast,Department of Medical Biochemistry, School of Medical Sciences, College of Health and Allied Sciences
[2] University of Cape Coast,Pharmacogenomics and Genomic Medicine Group, School of Medical Sciences, College of Health and Allied Sciences
[3] University of Cape Town,Division of Human Genetics, Department of Pathology, Faculty of Health Sciences
[4] University of Cape Coast,Department of Adult Health, School of Nursing and Midwifery, College of Health and Allied Sciences
[5] University of Cape Coast,Department of Pharmacotherapeutics and Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences Sciences, College of Health and Allied Sciences
来源
BMC Medical Genomics | / 17卷
关键词
CYP2D6; Tramadol; Opioid analgesics; Pharmacogenomics; Metabolism; Alleles;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 203 条
  • [1] Zanger UM(2004)Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry Naunyn Schmiedebergs Arch Pharmacol 369 23-37
  • [2] Raimundo S(2011)CYP2D6 in the metabolism of opioids for mild to moderate pain Pharmacology 87 274-85
  • [3] Eichelbaum M(2017)Prediction of CYP2D6 phenotype from genotype across world populations Genet Med 19 69-76
  • [4] Leppert W(2019)Updated clinical pharmacokinetics and pharmacodynamics of Oxycodone Clin Pharmacokinet 58 705-25
  • [5] Gaedigk A(2007)Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication Pharmacogenomics J 7 257-65
  • [6] Sangkuhl K(1999)Decreased capacity for debrisoquine metabolism among black tanzanians: analyses of the CYP2D6 genotype and phenotype Pharmacogenetics 9 707-14
  • [7] Whirl-Carrillo M(2014)Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update Clin Pharmacol Ther 95 376-82
  • [8] Klein T(2016)Pain services and prescription of opioid Drugs in Ghana Ghana Med J 50 62-2
  • [9] Leeder JS(2010)Access to pain treatment as a human right BMC Med 8 8-20
  • [10] Kinnunen M(2008)Opioid Complications and side effects Pain Physician 11 105-52