Successful operation for mitral regurgitation in a patient with Gilbert's syndrome

被引：2

作者：

Minami H. ^{[1
]}

Asada T. ^{[1
]}

Gan K. ^{[1
]}

Yamada A. ^{[1
]}

Yano Y. ^{[2
]}

机构：

[1] Department of Cardiovascular Surgery, Miki City Hospital, Miki, Hyogo 673-0402

[2] Department of Gastroenterology, Kobe University, Graduate School of Medicine, Kobe

来源：

General Thoracic and Cardiovascular Surgery | 2011年 / 59卷 / 5期

关键词：

Constitutional jaundice; Gilbert's syndrome; Heart surgery; Hyperbilirubinemia; Mitral valve replacement;

D O I：

10.1007/s11748-010-0688-6

中图分类号：

学科分类号：

摘要：

A 72-year-old woman complaining of dyspnea on effort was diagnosed as having mitral regurgitation (MR). Asymptomatic jaundice had initially been noticed during primary school, and an examination had shown hyperbilirubinemia. After the diagnosis of constitutional jaundice, she had remained well without further examination or medical treatment. Laboratory data showed a total serum bilirubin (TB) level of 12.2 mg/dl and a direct bilirubin level of 0.6 mg/dl. Transesophageal echocardiography showed severe MR, and we replaced the mitral valve. Postoperatively, genetic analyses identified constitutional jaundice as Gilbert's syndrome with Y486D mutation. The TB level gradually decreased. Four years after operation she is doing well with moderate hyperbilirubinemia and a TB level of 5 mg/dl. She is free from heart failure. © 2011 The Japanese Association for Thoracic Surgery.

引用

页码：344 / 346

页数：2

共 7 条

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