Management of Obstetric Antiphospholipid Syndrome

被引：0
作者：
Guilherme Ribeiro Ramires de Jesus
Flavia Cunha dos Santos
Camila Souto Oliveira
Wallace Mendes-Silva
Nilson Ramires de Jesus
Roger Abramino Levy
机构：
[1] Universidade do Estado do Rio de Janeiro,Department of Obstetrics, Faculdade de Ciências Médicas
[2] Universidade do Estado do Rio de Janeiro,Department of Obstetrics, Faculdade de Ciências Médicas
[3] Universidade do Estado do Rio de Janeiro,Department of Rheumatology, Faculdade de Ciências Médicas
[4] Universidade do Estado do Rio de Janeiro,Department of Obstetrics, Faculdade de Ciências Médicas
[5] Universidade do Estado do Rio de Janeiro,Department of Rheumatology, Faculdade de Ciências Médicas
来源：
Current Rheumatology Reports | 2012年 / 14卷
关键词：
Antiphospholipid syndrome; APS; Obstetric APS; Recurrent miscarriage; Thrombosis; Anticoagulation; Infertility; Fetal loss; Lupus; Management of APS; Management of obstetric APS;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Recurrent early miscarriages (excluding chromosomal anomalies), late fetal loss, and maternal thrombosis are characteristic of obstetric antiphospholipid syndrome (APS). Obstetric complications such as preeclampsia, fetal growth restriction, premature delivery, and fetal death also occur in higher frequency in APS patients than in the general population. A high-risk obstetric center is needed for proper evaluation of and intervention with pregnant women with APS. Association with lupus carries additional risk of thrombosis when antiphospholipid antibodies (aPLs) are present. Gestational results with live births are improved to about 80% when antithrombotic therapy is used, but failure in 20% to 30% of the cases despite correct treatment with low-dose aspirin with or without heparin reveals new pathways for pregnancy loss in APS and unmet needs. At the moment, there is no recommendation to investigate patients with infertility for the presence of aPLs.
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页码：79 / 86
页数：7
相关论文
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