Effects of hyperglycemia on oxidative stress and antioxidant potential in patients with type 2 diabetes

被引：7
作者：
Ikebuchi M. [1 ]
Nishio Y. [2 ]
Maegawa H. [2 ]
Kashiwagi A. [2 ]
机构：
[1] Ikebuchi Clinic, Osaka 547-0011, 2-4-16 Deto, Nagayoshi, Hirano
[2] Department of Medicine, Shiga University of Medical Science, Otsu
来源：
Diabetology International | 2010年 / 1卷 / 2期
关键词：
Antioxidant potential; Diabetes mellitus; Hyperglycemia; Metabolic syndrome; Oxidative stress;
D O I：
10.1007/s13340-010-0008-5
中图分类号：
学科分类号：
摘要：
Many in vitro studies have suggested that oxidative stress induced by hyperglycemic conditions has a pivotal role in the pathogenesis of vascular complications in diabetics. This study intended to evaluate the oxidative stress and antioxidant potential in patients with type 2 diabetes mellitus (DM), and to clarify the relation between oxidative stress and metabolic derangements including chronic hyperglycemia. We measured the levels of derivatives of reactive oxidative metabolites (ROM) and biological antioxidant potential (BAP) in 59 patients with type 2 DM and 10 healthy controls. Diabetic patients showed a significant increase in ROM levels and a decrease in adjusted BAP/ROM ratios compared with those of control. But no differences were found in BAP levels between the two groups. ROM levels were found to positively correlate with HbA1c, plasma glucose, and waist size, and adjusted BAP/ROM ratios negatively correlated with HbA1c, plasma glucose, waist size, and serum triglycerides. Stepwise multiple regression analysis indicated that HbA1c and waist size were independent factors contributing to the elevated ROM levels. The ROM level in patients with type 2 DM with metabolic syndrome was significantly higher than that in patients without metabolic syndrome. Glycemic control with glimepiride or miglitol for 3 months reduced ROM levels significantly by 9%. These results clearly demonstrate that glycemic control and visceral obesity are independently associated with an increasing oxidative stress in patients with type 2 DM. © 2010 Japan Diabetes Society.
引用
收藏
页码：72 / 77
页数：5
相关论文
共 22 条
  • [1] Giugliano D., Ceriello A., Paolisso G., Oxidative stress and diabetic vascular complications, Diabetes Care, 19, pp. 257-267, (1996)
  • [2] Beckman J.A., Creager M.A., Libby P., Diabetes and atherosclerosis, Jama, 287, pp. 2570-2581, (2002)
  • [3] Brownlee M., Biochemistry and molecular cell biology of diabetic complications, Nature, 414, pp. 813-820, (2001)
  • [4] Cerielloa P.L., Quagliaro L., Wang Y., Schnabel C.A., Ruggles J.A., Gloster M.A., Maggs D.G., Weyer C., Effects of pramlintide on postprandial glucose excursions and measures of oxidative stress in patients with type 1 diabetes, Diabetes Care, 28, pp. 632-637, (2005)
  • [5] Sakane N., Fujiwara S., Sano Y., Domichi M., Tsuzaki K., Matsuoka Y., Hamada T., Shiaga K., Kotani K., Oxidative stress, inflammation, and atherosclerotic changes in retinal arteries in the Japanese population
  • [6] result from the Mima study, Endocr J, 55, pp. 485-488, (2008)
  • [7] Vassalle C., Pratali L., Boni C., Mercuri A., Ndreu R., An oxidative stress score as a combined measure of the pro-oxidant and anti-oxidant counterparts in patients with coronary artery disease, Clin Biochem, 41, pp. 1162-1167, (2008)
  • [8] Nakayama K., Terawaki H., Nakayama M., Iwabuchi M., Sato T., Ito S., Reduction of serum antioxidative capacity during hemodialysis, Clin Exp Nephrol, 11, pp. 218-224, (2007)
  • [9] Nagata K., Hasegawa T., Hirokado Y., Kiyama K., Otsuki C., Lifestyle-related diseases and the oxidative stress regulation system, Jpn J Psychosom Med, 48, pp. 177-183, (2008)
  • [10] Report of the Committee on the classification and diagnostic criteria of diabetes mellitus, J Jpn Diabetes Soc, 53, 6, pp. 450-467, (2010)
123