Hierarchical functional gradients of pH-responsive self-assembled monolayers using dynamic covalent chemistry on surfaces

被引：0
作者：
Tauk L. [1 ,2 ,3 ]
Schröder A.P. [3 ]
Decher G. [2 ,3 ]
Giuseppone N. [1 ,2 ,3 ]
机构：
[1] SAMS Research Group
[2] International Centre for Frontier Research in Hemistry, University of Strasbourg
[3] Institut Charles Sadron, Centre National de la Recherche Scientifique, 67034 Strasbourg cedex 2, 23 rue du Loess
来源：
Nature Chemistry | 2009年 / 1卷 / 8期
关键词：
D O I：
10.1038/nchem.400
中图分类号：
学科分类号：
摘要：
Surface chemistry is an important field of research, especially for the study and design of (bio)nanostructures in which nearly every atom lies at an interface. Here we show that dynamic covalent chemistry is an efficient tool for functionalizing surfaces in such a way that their interfacial properties can be varied controllably in space and time. Modulation of pH is used to tune the fast, selective and reversible attachment of functional amines (with different pK a values) to an aldehyde-coated surface. To illustrate the potential of this technique, we developed dynamic self-assembled monolayers ('DynaSAMs'), which enable the hierarchical construction of mixed gradients comprising either small functional molecules or proteins. Control of the (bio)chemical composition at any point on the surface potentially provides a simple bottom-up method to access numerous surface patterns with a broad range of unctionalities. © 2009 Macmillan Publishers Limited. All rights reserved.
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页码：649 / 656
页数：7
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