Influence of operational variables on properties of piroxicam pellets prepared by extrusion-spheronization: A technical note

被引：0
|
作者：
Vivek R. Sinha
Manoj K. Agrawal
Rachna Kumria
Jayant R. Bhinge
机构：
[1] Panjab University,University Institute of Pharmaceutical Sciences
[2] Ranbaxy Laboratories Ltd,undefined
[3] Ind-Swift Laboratories Ltd,undefined
来源：
AAPS PharmSciTech | / 8卷 / 1期
关键词：
Extrusion; spheronization; pellets; microcrystalline cellulose;
D O I：
10.1208/pt0801020
中图分类号：
学科分类号：
摘要：
The processing conditions has a pronounced effect on the pellet properties. Drying conditions influenced the mean size and the drug release of the pellets. Because of the shrinking of the pellets upon drying at higher temperatures, the pellets also showed increased densities. Freeze drying almost prevented shrinking and thus led to the highest drug release. With an increase in the temperature of drying, the drug release rate decreased.
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