Differential expression of toll-like receptor 6 on granulocytes and monocytes implicates the role of microorganisms in Behcet’s disease etiopathogenesis

被引：0
作者：
Sule Yavuz
Yesim Elbir
Aysin Tulunay
Emel Eksioglu-Demiralp
Haner Direskeneli
机构：
[1] University of Marmara,Department of Rheumatology
[2] University of Marmara,Department of Haematology–Immunology
来源：
Rheumatology International | 2008年 / 28卷
关键词：
Behcet’s disease; Innate immunity cells; Toll-like receptors;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The objective of this study was to investigate the expressions of toll-like receptors on neutrophils and monocytes in Behcet’s disease (BD). Forty-two patients with BD were included in the study. Baseline and stimulated cells with heat shock protein-60 (HSP-60), lipopolysaccharide (LPS) and crude extract of Streptococcus sanguis (SS) were analyzed for toll-like receptor-1, -2, -4 and -6 expressions using flow cytometer. Results were confirmed using semi-quantitative PCR technique. The mean frequency of TLR-6 expressing granulocytes in BD patients was significantly lower than in controls (4.2 ± 0.6 vs. 9.2 ± 0.6 and 8.0 ± 1.4, BD vs. rheumatoid arthritis (RA) and healthy control (HC); P < 0.05). TLR-6 expressing granulocyte population was enhanced after stimulation with HSP-60 and SS (20 ± 0.5 and 12.8 ± 0.6, respectively). Decreased TLR-2 expression was noted in monocytes of BD patients after stimulation with HSP-60 and LPS (71.0 ± 0.5 and 73.0 ± 0.5; P < 0.02, for both antigens). Functional abnormalities of these receptors or different activation cascades by different microorganisms are associated with disease pathogenesis in Behcet’s disease.
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页码：401 / 406
页数：5
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